UPK2_HUMAN
ID UPK2_HUMAN Reviewed; 184 AA.
AC O00526; B0YJ92; O00457; Q53YV0;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Uroplakin-2;
DE Short=UP2;
DE AltName: Full=Uroplakin II;
DE Short=UPII;
DE Flags: Precursor;
GN Name=UPK2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Ureter;
RX PubMed=9846985; DOI=10.1016/s0002-9440(10)65709-4;
RA Lobban E.D., Smith B.A., Hall G.D., Harnden P., Roberts P., Selby P.J.,
RA Trejdosiewicz L.K., Southgate J.;
RT "Uroplakin gene expression by normal and neoplastic human urothelium.";
RL Am. J. Pathol. 153:1957-1967(1998).
RN [2]
RP SEQUENCE REVISION TO 163.
RA Smith B.A.;
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=12792753;
RA Hirata H., Hisatomi H., Kawakita M., Nagao K., Yamamoto S., Hikiji K.,
RA Nakamoto T., Harasawa H., Kaneko N., Matsuda T., Yamamoto M., Kanamaru T.;
RT "Genetic detection for hematogenous micrometastasis in patients with
RT various types of malignant tumors using Uroplakin II derived primers in
RT polymerase chain reaction.";
RL Oncol. Rep. 10:963-966(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Urinary bladder;
RA Tong Q.S., Zheng L.D., Chen F.M., Zeng F.Q., Zhao J., Wang L., Lu G.C.;
RT "Cloning of human uroplakin II gene from Chinese transitional cell
RT carcinoma of bladder patients.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NHLBI resequencing and genotyping service (RS&G);
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 146-184.
RC TISSUE=Urinary bladder carcinoma;
RA Su S.L.;
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a highly
CC specialized biomembrane elaborated by terminally differentiated
CC urothelial cells. May play an important role in regulating the assembly
CC of the AUM (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with uroplakin-1a (UPK1A). {ECO:0000250}.
CC -!- INTERACTION:
CC O00526; Q86Y34: ADGRG3; NbExp=3; IntAct=EBI-10179682, EBI-17979264;
CC O00526; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-10179682, EBI-19125216;
CC O00526; P07307-3: ASGR2; NbExp=3; IntAct=EBI-10179682, EBI-12808270;
CC O00526; O75787: ATP6AP2; NbExp=3; IntAct=EBI-10179682, EBI-2512037;
CC O00526; J3KQ12: BSCL2; NbExp=3; IntAct=EBI-10179682, EBI-11532900;
CC O00526; Q6UXG8-3: BTNL9; NbExp=3; IntAct=EBI-10179682, EBI-17953245;
CC O00526; P04233-2: CD74; NbExp=4; IntAct=EBI-10179682, EBI-12222807;
CC O00526; O95471: CLDN7; NbExp=3; IntAct=EBI-10179682, EBI-740744;
CC O00526; Q6ZS10: CLEC17A; NbExp=3; IntAct=EBI-10179682, EBI-11977093;
CC O00526; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-10179682, EBI-11989440;
CC O00526; P12314: FCGR1A; NbExp=3; IntAct=EBI-10179682, EBI-2869867;
CC O00526; P12318-2: FCGR2A; NbExp=3; IntAct=EBI-10179682, EBI-17187481;
CC O00526; P55899: FCGRT; NbExp=3; IntAct=EBI-10179682, EBI-2833934;
CC O00526; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-10179682, EBI-12142257;
CC O00526; Q99795: GPA33; NbExp=3; IntAct=EBI-10179682, EBI-4289554;
CC O00526; P05981: HPN; NbExp=3; IntAct=EBI-10179682, EBI-12816745;
CC O00526; Q9NQX7-3: ITM2C; NbExp=3; IntAct=EBI-10179682, EBI-12811565;
CC O00526; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-10179682, EBI-749265;
CC O00526; P43628: KIR2DL3; NbExp=3; IntAct=EBI-10179682, EBI-8632435;
CC O00526; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-10179682, EBI-17272405;
CC O00526; Q9H400: LIME1; NbExp=3; IntAct=EBI-10179682, EBI-2830566;
CC O00526; P60201-2: PLP1; NbExp=3; IntAct=EBI-10179682, EBI-12188331;
CC O00526; Q96K19-5: RNF170; NbExp=3; IntAct=EBI-10179682, EBI-12055631;
CC O00526; A1A5C7-2: SLC22A23; NbExp=3; IntAct=EBI-10179682, EBI-12081840;
CC O00526; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-10179682, EBI-10226799;
CC O00526; Q8TAV4: STOML3; NbExp=3; IntAct=EBI-10179682, EBI-12900395;
CC O00526; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-10179682, EBI-2821497;
CC O00526; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-10179682, EBI-12345267;
CC O00526; O14788: TNFSF11; NbExp=3; IntAct=EBI-10179682, EBI-7404021;
CC O00526; O43557: TNFSF14; NbExp=3; IntAct=EBI-10179682, EBI-524131;
CC O00526; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-10179682, EBI-10243654;
CC O00526; Q8WWF5: ZNRF4; NbExp=3; IntAct=EBI-10179682, EBI-2129267;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1A
CC is a prerequisite to exit out of the endoplasmic reticulum (ER).
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in ureter. {ECO:0000269|PubMed:9846985}.
CC -!- SIMILARITY: Belongs to the uroplakin-2 family. {ECO:0000305}.
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DR EMBL; Y13645; CAA73996.1; -; mRNA.
DR EMBL; AB078607; BAB84089.1; -; Genomic_DNA.
DR EMBL; AY455312; AAR19396.1; -; mRNA.
DR EMBL; EF445028; ACA06070.1; -; Genomic_DNA.
DR EMBL; BC113900; AAI13901.1; -; mRNA.
DR EMBL; AF000562; AAB58416.1; -; mRNA.
DR CCDS; CCDS8404.1; -.
DR PIR; T09609; T09609.
DR RefSeq; NP_006751.1; NM_006760.3.
DR AlphaFoldDB; O00526; -.
DR BioGRID; 113225; 162.
DR IntAct; O00526; 32.
DR STRING; 9606.ENSP00000264031; -.
DR TCDB; 8.A.90.1.1; the uroplakin 2/3 (upk2/3) family.
DR GlyGen; O00526; 3 sites.
DR iPTMnet; O00526; -.
DR PhosphoSitePlus; O00526; -.
DR BioMuta; UPK2; -.
DR jPOST; O00526; -.
DR MassIVE; O00526; -.
DR MaxQB; O00526; -.
DR PaxDb; O00526; -.
DR PeptideAtlas; O00526; -.
DR PRIDE; O00526; -.
DR ProteomicsDB; 47956; -.
DR TopDownProteomics; O00526; -.
DR Antibodypedia; 32551; 88 antibodies from 17 providers.
DR DNASU; 7379; -.
DR Ensembl; ENST00000264031.3; ENSP00000264031.2; ENSG00000110375.3.
DR GeneID; 7379; -.
DR KEGG; hsa:7379; -.
DR MANE-Select; ENST00000264031.3; ENSP00000264031.2; NM_006760.4; NP_006751.1.
DR UCSC; uc001puh.4; human.
DR CTD; 7379; -.
DR DisGeNET; 7379; -.
DR GeneCards; UPK2; -.
DR HGNC; HGNC:12579; UPK2.
DR HPA; ENSG00000110375; Tissue enriched (urinary).
DR MIM; 611558; gene.
DR neXtProt; NX_O00526; -.
DR OpenTargets; ENSG00000110375; -.
DR PharmGKB; PA37211; -.
DR VEuPathDB; HostDB:ENSG00000110375; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00390000006115; -.
DR HOGENOM; CLU_126065_0_0_1; -.
DR InParanoid; O00526; -.
DR OMA; PRRNMES; -.
DR OrthoDB; 1415812at2759; -.
DR PhylomeDB; O00526; -.
DR TreeFam; TF337797; -.
DR PathwayCommons; O00526; -.
DR SignaLink; O00526; -.
DR BioGRID-ORCS; 7379; 7 hits in 1067 CRISPR screens.
DR GeneWiki; UPK2; -.
DR GenomeRNAi; 7379; -.
DR Pharos; O00526; Tbio.
DR PRO; PR:O00526; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; O00526; protein.
DR Bgee; ENSG00000110375; Expressed in endometrium epithelium and 92 other tissues.
DR Genevisible; O00526; HS.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0030855; P:epithelial cell differentiation; IDA:UniProtKB.
DR CDD; cd09967; UP_II; 1.
DR InterPro; IPR009952; Uroplakin-2.
DR PANTHER; PTHR17573; PTHR17573; 1.
DR Pfam; PF07353; Uroplakin_II; 1.
DR PIRSF; PIRSF016439; Uroplakin_II; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cleavage on pair of basic residues; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..84
FT /evidence="ECO:0000250"
FT /id="PRO_0000022630"
FT CHAIN 85..184
FT /note="Uroplakin-2"
FT /id="PRO_0000022631"
FT TOPO_DOM 85..155
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..184
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 47
FT /note="A -> S (in dbSNP:rs3886020)"
FT /id="VAR_051473"
FT VARIANT 160
FT /note="T -> M (in dbSNP:rs45530531)"
FT /id="VAR_062246"
FT CONFLICT 149
FT /note="G -> A (in Ref. 7; AAB58416)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 184 AA; 19438 MW; 83D963F06050A585 CRC64;
MAPLLPIRTL PLILILLALL SPGAADFNIS SLSGLLSPAL TESLLVALPP CHLTGGNATL
MVRRANDSKV VTSSFVVPPC RGRRELVSVV DSGAGFTVTR LSAYQVTNLV PGTKFYISYL
VKKGTATESS REIPMSTLPR RNMESIGLGM ARTGGMVVIT VLLSVAMFLL VLGFIIALAL
GSRK
