UPK2_MOUSE
ID UPK2_MOUSE Reviewed; 184 AA.
AC P38575;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Uroplakin-2;
DE Short=UP2;
DE AltName: Full=Uroplakin II;
DE Short=UPII;
DE Flags: Precursor;
GN Name=Upk2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8175808; DOI=10.1016/s0021-9258(17)36889-8;
RA Wu X.-R., Lin J.-H., Walz T., Haener M., Yu J., Aebi U., Sun T.-T.;
RT "Mammalian uroplakins. A group of highly conserved urothelial
RT differentiation-related membrane proteins.";
RL J. Biol. Chem. 269:13716-13724(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ;
RX PubMed=7846036; DOI=10.1073/pnas.92.3.679;
RA Lin J.-H., Zhao H., Sun T.-T.;
RT "A tissue-specific promoter that can drive a foreign gene to express in the
RT suprabasal urothelial cells of transgenic mice.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:679-683(1995).
CC -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a highly
CC specialized biomembrane elaborated by terminally differentiated
CC urothelial cells. May play an important role in regulating the assembly
CC of the AUM.
CC -!- SUBUNIT: Interacts with uroplakin-1a (UPK1A). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1A
CC is a prerequisite to exit out of the endoplasmic reticulum (ER).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the uroplakin-2 family. {ECO:0000305}.
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DR EMBL; U08030; AAA19602.1; -; mRNA.
DR EMBL; U14421; AAC52158.1; -; Genomic_DNA.
DR CCDS; CCDS23112.1; -.
DR PIR; A55603; A54135.
DR AlphaFoldDB; P38575; -.
DR STRING; 10090.ENSMUSP00000040481; -.
DR GlyGen; P38575; 3 sites.
DR PhosphoSitePlus; P38575; -.
DR PaxDb; P38575; -.
DR PRIDE; P38575; -.
DR ProteomicsDB; 297870; -.
DR MGI; MGI:98913; Upk2.
DR eggNOG; KOG2294; Eukaryota.
DR InParanoid; P38575; -.
DR PhylomeDB; P38575; -.
DR PRO; PR:P38575; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P38575; protein.
DR GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
DR GO; GO:0120001; C:apical plasma membrane urothelial plaque; IDA:MGI.
DR GO; GO:0030855; P:epithelial cell differentiation; ISO:MGI.
DR CDD; cd09967; UP_II; 1.
DR InterPro; IPR009952; Uroplakin-2.
DR PANTHER; PTHR17573; PTHR17573; 1.
DR Pfam; PF07353; Uroplakin_II; 1.
DR PIRSF; PIRSF016439; Uroplakin_II; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cleavage on pair of basic residues; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..84
FT /evidence="ECO:0000255"
FT /id="PRO_0000022632"
FT CHAIN 85..184
FT /note="Uroplakin-2"
FT /id="PRO_0000022633"
FT TOPO_DOM 85..155
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..184
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 184 AA; 19572 MW; E15E00C1EB1A7253 CRC64;
MASTLPVQTL PLILILLAVL APGTADFNIS SLSGLLSPAL TESLLIALPP CHLTGGNATL
MVRRANDSKV VKSDFVVPPC RGRRELVSVV DSGSGYTVTR LSAYQVTNLT PGTKYYISYR
VQKGTSTESS PETPMSTLPR KNMESIGLGM ARTGGMVVIT VLLSVAMFLL VVGLIVALHW
DARK