UPK2_PIG
ID UPK2_PIG Reviewed; 184 AA.
AC Q95L04; Q7M2K0; Q9TUP8;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 3.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Uroplakin-2;
DE Short=UP2;
DE AltName: Full=Uroplakin II;
DE Short=UPII;
DE Flags: Precursor;
GN Name=UPK2;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12054551; DOI=10.1016/s0006-291x(02)00295-4;
RA Kwon D.-N., Seo H.G., Kim J.-H.;
RT "Cloning, sequencing, and expression analysis of the porcine uroplakin II
RT gene.";
RL Biochem. Biophys. Res. Commun. 293:862-869(2002).
CC -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a highly
CC specialized biomembrane elaborated by terminally differentiated
CC urothelial cells. May play an important role in regulating the assembly
CC of the AUM (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with uroplakin-1a (UPK1A). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1A
CC is a prerequisite to exit out of the endoplasmic reticulum (ER).
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed only in the urothelium. Localizes to
CC urothelial superficial cells. {ECO:0000269|PubMed:12054551}.
CC -!- SIMILARITY: Belongs to the uroplakin-2 family. {ECO:0000305}.
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DR EMBL; AY044189; AAK96021.1; -; Genomic_DNA.
DR EMBL; AF164141; AAD49848.2; -; mRNA.
DR PIR; JC7839; JC7839.
DR RefSeq; NP_999177.1; NM_214012.1.
DR AlphaFoldDB; Q95L04; -.
DR STRING; 9823.ENSSSCP00000016023; -.
DR PaxDb; Q95L04; -.
DR PeptideAtlas; Q95L04; -.
DR GeneID; 397075; -.
DR KEGG; ssc:397075; -.
DR CTD; 7379; -.
DR eggNOG; KOG2294; Eukaryota.
DR InParanoid; Q95L04; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR CDD; cd09967; UP_II; 1.
DR InterPro; IPR009952; Uroplakin-2.
DR PANTHER; PTHR17573; PTHR17573; 1.
DR Pfam; PF07353; Uroplakin_II; 1.
DR PIRSF; PIRSF016439; Uroplakin_II; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cleavage on pair of basic residues; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..84
FT /evidence="ECO:0000255"
FT /id="PRO_0000022634"
FT CHAIN 85..184
FT /note="Uroplakin-2"
FT /id="PRO_0000022635"
FT TOPO_DOM 85..155
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..184
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 141..145
FT /note="KNMEG -> RKAEA (in Ref. 1; AAD49848)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="R -> P (in Ref. 1; AAD49848)"
FT /evidence="ECO:0000305"
FT CONFLICT 160
FT /note="T -> Q (in Ref. 1; AAD49848)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 184 AA; 19318 MW; 75E168C2DDF19FC0 CRC64;
MASPLPVRTL PLILILLAVL APGASDFNIS SLSGPLSPAL TESLLVALPP CHLTGGNATL
MVRRANDSKV VKSSFMVPPC RGRRELVSVV DSGSGFTVTR LSAYQVTNLV PGTKYYISYL
VTKGASTESS REIPMSTLPR KNMEGIGLGM ARTGGMVVIT VLLSVAMFLL VVGFITALAL
GARK
