UPK3A_BOVIN
ID UPK3A_BOVIN Reviewed; 287 AA.
AC P38574;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Uroplakin-3a;
DE Short=UP3a;
DE AltName: Full=Uroplakin III;
DE Short=UPIII;
DE Flags: Precursor;
GN Name=UPK3A; Synonyms=UPK3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 19-45; 174-181 AND
RP 209-235.
RC TISSUE=Urinary bladder urothelium;
RX PubMed=8270634; DOI=10.1242/jcs.106.1.31;
RA Wu X.-R., Sun T.-T.;
RT "Molecular cloning of a 47 kDa tissue-specific and differentiation-
RT dependent urothelial cell surface glycoprotein.";
RL J. Cell Sci. 106:31-43(1993).
RN [2]
RP INTERACTION WITH UPK1B, AND SUBCELLULAR LOCATION.
RX PubMed=12475947; DOI=10.1091/mbc.e02-04-0211;
RA Tu L., Sun T.-T., Kreibich G.;
RT "Specific heterodimer formation is a prerequisite for uroplakins to exit
RT from the endoplasmic reticulum.";
RL Mol. Biol. Cell 13:4221-4230(2002).
CC -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a highly
CC specialized biomembrane elaborated by terminally differentiated
CC urothelial cells. May play an important role in AUM-cytoskeleton
CC interaction in terminally differentiated urothelial cells. It also
CC contributes to the formation of urothelial glycocalyx which may play an
CC important role in preventing bacterial adherence.
CC -!- SUBUNIT: Heterodimer with uroplakin-1B (UPK1B).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:12475947}; Single-pass type I membrane protein
CC {ECO:0000269|PubMed:12475947}. Note=Heterodimer formation with UPK1B is
CC a prerequisite to exit out of the endoplasmic reticulum (ER).
CC -!- TISSUE SPECIFICITY: Bladder epithelium.
CC -!- SIMILARITY: Belongs to the uroplakin-3 family. {ECO:0000305}.
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DR EMBL; L19542; AAC37309.1; -; mRNA.
DR PIR; I45986; I45986.
DR RefSeq; NP_777134.1; NM_174709.3.
DR AlphaFoldDB; P38574; -.
DR STRING; 9913.ENSBTAP00000013081; -.
DR PaxDb; P38574; -.
DR Ensembl; ENSBTAT00000013081; ENSBTAP00000013081; ENSBTAG00000009913.
DR GeneID; 100336102; -.
DR KEGG; bta:100336102; -.
DR CTD; 7380; -.
DR VEuPathDB; HostDB:ENSBTAG00000009913; -.
DR VGNC; VGNC:36687; UPK3A.
DR eggNOG; ENOG502S14V; Eukaryota.
DR GeneTree; ENSGT00940000153392; -.
DR HOGENOM; CLU_082608_1_0_1; -.
DR InParanoid; P38574; -.
DR OMA; EKPFCVF; -.
DR OrthoDB; 1269506at2759; -.
DR TreeFam; TF336628; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000009913; Expressed in urethra and 15 other tissues.
DR GO; GO:0120001; C:apical plasma membrane urothelial plaque; IDA:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0005198; F:structural molecule activity; IDA:UniProtKB.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0055075; P:potassium ion homeostasis; IEA:Ensembl.
DR GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR GO; GO:0015840; P:urea transport; IBA:GO_Central.
DR GO; GO:0060157; P:urinary bladder development; IEA:Ensembl.
DR GO; GO:0006833; P:water transport; IBA:GO_Central.
DR InterPro; IPR024831; Uroplakin-3.
DR InterPro; IPR024825; Uroplakin-3a.
DR PANTHER; PTHR15446; PTHR15446; 1.
DR PANTHER; PTHR15446:SF17; PTHR15446:SF17; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000269|PubMed:8270634"
FT CHAIN 19..287
FT /note="Uroplakin-3a"
FT /id="PRO_0000022636"
FT TOPO_DOM 19..207
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 243..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 287 AA; 30757 MW; 177185A017E233B5 CRC64;
MPPLWVVLAL GCLRLGSGVN LQPQLASVTF ATNNPTLTTV ALEKPLCMFD SSAALHGTYE
VYLYVLVDSA SFRNASVQDS TKTPLSSTFQ QTQGGRTGPY KAAAFDLTPC SDSPSLDAVR
DVSRASEILN AYLIRVGTNG TCLLDPNFQG LCNPPLSAAT EYRFKYVLVN MSSGLVQDQT
LWSDPIRTDR LTLYSAIDTW PGRRSGGMIV ITSILGSLPF FLLIGFAGAI VLSLVDRGDA
DGATSHDSQI TQEAVPKSLG TSEPSYTSVN RGPSLDRAEV YASKLQD
