ID   UPK3B_BOVIN             Reviewed;         279 AA.
AC   Q864V4;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Uroplakin-3b;
DE            Short=UP3b;
DE   AltName: Full=Uroplakin IIIb;
DE            Short=UPIIIb;
DE   AltName: Full=p35;
DE   Flags: Precursor;
GN   Name=UPK3B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 58-70; 163-177 AND 268-279,
RP   INTERACTION WITH UPK1B, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Urinary bladder urothelium;
RX   PubMed=12446744; DOI=10.1083/jcb.200204102;
RA   Deng F.-M., Liang F.-X., Tu L., Resing K.A., Hu P., Supino M., Hu C.-C.A.,
RA   Zhou G., Ding M., Kreibich G., Sun T.-T.;
RT   "Uroplakin IIIb, a urothelial differentiation marker, dimerizes with
RT   uroplakin Ib as an early step of urothelial plaque assembly.";
RL   J. Cell Biol. 159:685-694(2002).
CC   -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a highly
CC       specialized biomembrane elaborated by terminally differentiated
CC       urothelial cells. May play an important role in AUM-cytoskeleton
CC       interaction in terminally differentiated urothelial cells. It also
CC       contributes to the formation of urothelial glycocalyx which may play an
CC       important role in preventing bacterial adherence (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with uroplakin-1B (UPK1B).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1B
CC       is a prerequisite to exit out of the endoplasmic reticulum (ER).
CC       {ECO:0000269|PubMed:12446744}.
CC   -!- TISSUE SPECIFICITY: Expression is urothelium-specific.
CC       {ECO:0000269|PubMed:12446744}.
CC   -!- SIMILARITY: Belongs to the uroplakin-3 family. {ECO:0000305}.
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DR   EMBL; AY233461; AAO89506.1; -; mRNA.
DR   RefSeq; NP_001012690.1; NM_001012672.1.
DR   AlphaFoldDB; Q864V4; -.
DR   STRING; 9913.ENSBTAP00000041883; -.
DR   PaxDb; Q864V4; -.
DR   Ensembl; ENSBTAT00000044381; ENSBTAP00000041883; ENSBTAG00000021430.
DR   GeneID; 282115; -.
DR   KEGG; bta:282115; -.
DR   CTD; 105375355; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021430; -.
DR   VGNC; VGNC:107016; UPK3B.
DR   eggNOG; ENOG502RZJD; Eukaryota.
DR   GeneTree; ENSGT00940000153392; -.
DR   HOGENOM; CLU_082608_0_0_1; -.
DR   InParanoid; Q864V4; -.
DR   OMA; CEPGQDP; -.
DR   OrthoDB; 1269506at2759; -.
DR   TreeFam; TF336628; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000021430; Expressed in urethra and 101 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   InterPro; IPR024831; Uroplakin-3.
DR   InterPro; IPR024828; Uroplakin-3b.
DR   PANTHER; PTHR15446; PTHR15446; 1.
DR   PANTHER; PTHR15446:SF15; PTHR15446:SF15; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..279
FT                   /note="Uroplakin-3b"
FT                   /id="PRO_0000022639"
FT   TOPO_DOM        27..200
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..279
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   279 AA;  30587 MW;  817D1D7412F18758 CRC64;
     MGLPSRQPRL WLLLLVVLGW PQPCLTLDLI PYTPRITSWD LEGKVTATTF SLEQPRCVLD
     RHSSAADTVW LVVAFSNASR VFQNPQTLAE IPASPRLLTD GHYMTLPLTM DQLPCEDPAD
     GSGRAPVLRV GNDAGCLADL HQPRYCNAPL PGPGPYRVKF LLTNSRGSPQ AETRWSDLIA
     LRQGKSPGSI DTWPGRRSGD MIIITSILSS LAGLLLLAFL AASSVRFSSL WWPEEAPEQL
     RIGSFMGKRY MTHHIPPSEA ATLPVGCEPG LERFPSLSP