UPK3L_HUMAN
ID UPK3L_HUMAN Reviewed; 263 AA.
AC B0FP48; T2F9S8;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Uroplakin-3b-like protein 1 {ECO:0000312|HGNC:HGNC:37278};
DE Flags: Precursor;
GN Name=UPK3BL1 {ECO:0000312|HGNC:HGNC:37278}; Synonyms=UPLP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Eye;
RA Wistow G.;
RT "Human uroplakin-like protein.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=24450554; DOI=10.1186/1471-2148-14-13;
RA Desalle R., Chicote J.U., Sun T.T., Garcia-Espana A.;
RT "Generation of divergent uroplakin tetraspanins and their partners during
RT vertebrate evolution: identification of novel uroplakins.";
RL BMC Evol. Biol. 14:13-13(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the uroplakin-3 family. {ECO:0000305}.
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DR EMBL; EU341824; ABY56115.1; -; mRNA.
DR EMBL; KF150200; AGV74289.1; -; mRNA.
DR EMBL; AC105052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS47675.1; -.
DR RefSeq; NP_001107875.1; NM_001114403.2.
DR RefSeq; XP_016868385.1; XM_017012896.1.
DR AlphaFoldDB; B0FP48; -.
DR BioGRID; 756078; 41.
DR IntAct; B0FP48; 18.
DR TCDB; 8.A.90.2.3; the uroplakin 2/3 (upk2/3) family.
DR GlyConnect; 1888; 3 N-Linked glycans (2 sites).
DR GlyGen; B0FP48; 5 sites, 3 N-linked glycans (2 sites).
DR iPTMnet; B0FP48; -.
DR PhosphoSitePlus; B0FP48; -.
DR BioMuta; UPK3BL1; -.
DR MassIVE; B0FP48; -.
DR PaxDb; B0FP48; -.
DR PeptideAtlas; B0FP48; -.
DR PRIDE; B0FP48; -.
DR ProteomicsDB; 2542; -.
DR Antibodypedia; 74094; 16 antibodies from 8 providers.
DR DNASU; 100134938; -.
DR Ensembl; ENST00000340457.8; ENSP00000342938.8; ENSG00000267368.1.
DR GeneID; 100134938; -.
DR KEGG; hsa:100134938; -.
DR MANE-Select; ENST00000340457.8; ENSP00000342938.8; NM_001114403.3; NP_001107875.1.
DR MANE-Select; ENST00000644544.2; ENSP00000494359.1; NM_001363506.2; NP_001350435.1.
DR CTD; 100134938; -.
DR GeneCards; UPK3BL1; -.
DR HGNC; HGNC:37278; UPK3BL1.
DR HPA; ENSG00000267368; Tissue enhanced (esophagus).
DR neXtProt; NX_B0FP48; -.
DR OpenTargets; ENSG00000267368; -.
DR PharmGKB; PA165618441; -.
DR VEuPathDB; HostDB:ENSG00000267368; -.
DR eggNOG; ENOG502S22J; Eukaryota.
DR HOGENOM; CLU_082608_0_0_1; -.
DR InParanoid; B0FP48; -.
DR OMA; IYTCYDT; -.
DR OrthoDB; 1269506at2759; -.
DR PhylomeDB; B0FP48; -.
DR TreeFam; TF336628; -.
DR PathwayCommons; B0FP48; -.
DR SignaLink; B0FP48; -.
DR BioGRID-ORCS; 100134938; 108 hits in 1020 CRISPR screens.
DR BioGRID-ORCS; 107983993; 0 hits in 4 CRISPR screens.
DR Pharos; B0FP48; Tdark.
DR PRO; PR:B0FP48; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; B0FP48; protein.
DR Bgee; ENSG00000267368; Expressed in lower esophagus mucosa and 93 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR024831; Uroplakin-3.
DR InterPro; IPR024827; Uroplakin-3b-like_1/2.
DR PANTHER; PTHR15446; PTHR15446; 1.
DR PANTHER; PTHR15446:SF2; PTHR15446:SF2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..263
FT /note="Uroplakin-3b-like protein 1"
FT /id="PRO_0000375087"
FT TOPO_DOM 34..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 76
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 263 AA; 28385 MW; CBA7419B03F7A57E CRC64;
MDNSWRLGPA IGLSAGQSQL LVSLLLLLTR VQPGTDVAAP EHISYVPQLS NDTLAGRLTL
STFTLEQPLG QFSSHNISDL DTIWLVVALS NATQSFTAPR TNQDIPAPAN FSQRGYYLTL
RANRVLYQTR GQLHVLRVGN DTHCQPTKIG CNHPLPGPGP YRVKFLVMND EGPVAETKWS
SDTRLQQAQA LRAVPGPQSP GTVVIIAILS ILLAVLLTVL LAVLIYTCFN SCRSTSLSGP
EEAGSVRRYT THLAFSTPAE GAS
