UPK3L_MOUSE
ID UPK3L_MOUSE Reviewed; 249 AA.
AC Q9D701; A0AUM6; Q4KL12;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Uroplakin-3b-like protein 1 {ECO:0000250|UniProtKB:B0FP48};
DE Flags: Precursor;
GN Name=Upk3bl1 {ECO:0000250|UniProtKB:B0FP48};
GN Synonyms=Upk3bl {ECO:0000312|MGI:MGI:1916915};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thyroid;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the uroplakin-3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH99515.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI15564.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK009780; BAB26500.1; -; mRNA.
DR EMBL; BC099515; AAH99515.1; ALT_INIT; mRNA.
DR EMBL; BC115563; AAI15564.1; ALT_INIT; mRNA.
DR EMBL; BC115564; AAI15565.1; -; mRNA.
DR RefSeq; NP_081434.1; NM_027158.1.
DR RefSeq; XP_006504557.2; XM_006504494.3.
DR AlphaFoldDB; Q9D701; -.
DR GlyGen; Q9D701; 3 sites.
DR iPTMnet; Q9D701; -.
DR PhosphoSitePlus; Q9D701; -.
DR PaxDb; Q9D701; -.
DR PRIDE; Q9D701; -.
DR GeneID; 69665; -.
DR KEGG; mmu:69665; -.
DR UCSC; uc008zzs.1; mouse.
DR CTD; 69665; -.
DR MGI; MGI:1916915; Upk3bl.
DR eggNOG; ENOG502S22J; Eukaryota.
DR InParanoid; Q9D701; -.
DR OrthoDB; 1269506at2759; -.
DR PhylomeDB; Q9D701; -.
DR BioGRID-ORCS; 69665; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q9D701; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9D701; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR024831; Uroplakin-3.
DR InterPro; IPR024827; Uroplakin-3b-like_1/2.
DR PANTHER; PTHR15446; PTHR15446; 1.
DR PANTHER; PTHR15446:SF2; PTHR15446:SF2; 1.
DR SUPFAM; SSF48113; SSF48113; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..249
FT /note="Uroplakin-3b-like protein 1"
FT /id="PRO_0000375088"
FT TOPO_DOM 27..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 133
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 218
FT /note="C -> CS (in Ref. 2; AAI15564)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 27250 MW; A85886E64064F26A CRC64;
MGPHGKQSVL RMPLLLLLTC VQSGTGLESI NYAPQLLGAT LEGRLTQSTF TLEQPLGQFK
NVNLSDPDPI WLVVAHSNAA QNFTAPRKVE DRHAPANFDR NGYYLTLRAN RVHYKGGQPD
SQLRVLRVGN DNNCSLESQG CNSPLPGAGP YRVKFLAMSA EGPVAETLWS EEIYLQQAQT
FREAPGSQGK GTVVIIAFLS ILLAILLVVF LVLVISACLS TSGSSPEEQV RMRHYHTHHM
GSLRAERSS
