UPKL2_HUMAN
ID UPKL2_HUMAN Reviewed; 263 AA.
AC E5RIL1;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2017, sequence version 2.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Uroplakin-3b-like protein 2 {ECO:0000305};
DE Flags: Precursor;
GN Name=UPK3BL2 {ECO:0000312|HGNC:HGNC:53444};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the uroplakin-3 family. {ECO:0000305}.
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DR EMBL; AC093668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS87532.1; -.
DR RefSeq; NP_001107875.1; NM_001114403.2.
DR RefSeq; XP_016868385.1; XM_017012896.1.
DR AlphaFoldDB; E5RIL1; -.
DR GlyGen; E5RIL1; 5 sites.
DR iPTMnet; E5RIL1; -.
DR PhosphoSitePlus; E5RIL1; -.
DR BioMuta; HGNC:53444; -.
DR MassIVE; E5RIL1; -.
DR PaxDb; E5RIL1; -.
DR PRIDE; E5RIL1; -.
DR ProteomicsDB; 16320; -.
DR DNASU; 100134938; -.
DR Ensembl; ENST00000644544.1; ENSP00000494359.1; ENSG00000284981.1.
DR GeneID; 100134938; -.
DR KEGG; hsa:100134938; -.
DR MANE-Select; ENST00000340457.8; ENSP00000342938.8; NM_001114403.3; NP_001107875.1.
DR MANE-Select; ENST00000644544.2; ENSP00000494359.1; NM_001363506.2; NP_001350435.1.
DR UCSC; uc064gov.1; human.
DR CTD; 100134938; -.
DR GeneCards; UPK3BL2; -.
DR HGNC; HGNC:53444; UPK3BL2.
DR HPA; ENSG00000284981; Tissue enhanced (esophagus, lymphoid tissue).
DR neXtProt; NX_E5RIL1; -.
DR OpenTargets; ENSG00000267368; -.
DR VEuPathDB; HostDB:ENSG00000284981; -.
DR GeneTree; ENSGT00940000153392; -.
DR HOGENOM; CLU_082608_0_0_1; -.
DR InParanoid; E5RIL1; -.
DR OMA; AWATQNF; -.
DR OrthoDB; 1269506at2759; -.
DR PhylomeDB; E5RIL1; -.
DR TreeFam; TF336628; -.
DR PathwayCommons; E5RIL1; -.
DR SignaLink; E5RIL1; -.
DR Pharos; E5RIL1; Tdark.
DR PRO; PR:E5RIL1; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; E5RIL1; protein.
DR Bgee; ENSG00000284981; Expressed in granulocyte and 91 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR024831; Uroplakin-3.
DR InterPro; IPR024827; Uroplakin-3b-like_1/2.
DR PANTHER; PTHR15446; PTHR15446; 1.
DR PANTHER; PTHR15446:SF2; PTHR15446:SF2; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..263
FT /note="Uroplakin-3b-like protein 2"
FT /evidence="ECO:0000255"
FT /id="PRO_5003196876"
FT TOPO_DOM 34..204
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 76
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 263 AA; 28385 MW; CBA7419B03F7A57E CRC64;
MDNSWRLGPA IGLSAGQSQL LVSLLLLLTR VQPGTDVAAP EHISYVPQLS NDTLAGRLTL
STFTLEQPLG QFSSHNISDL DTIWLVVALS NATQSFTAPR TNQDIPAPAN FSQRGYYLTL
RANRVLYQTR GQLHVLRVGN DTHCQPTKIG CNHPLPGPGP YRVKFLVMND EGPVAETKWS
SDTRLQQAQA LRAVPGPQSP GTVVIIAILS ILLAVLLTVL LAVLIYTCFN SCRSTSLSGP
EEAGSVRRYT THLAFSTPAE GAS
