CA424_CONBU
ID CA424_CONBU Reviewed; 71 AA.
AC P0CY79;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 21.
DE RecName: Full=Conotoxin Bu24;
DE Flags: Precursor;
OS Conus bullatus (Bubble cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Textilia.
OX NCBI_TaxID=89438;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=21266071; DOI=10.1186/1471-2164-12-60;
RA Hu H., Bandyopadhyay P.K., Olivera B.M., Yandell M.;
RT "Characterization of the Conus bullatus genome and its venom-duct
RT transcriptome.";
RL BMC Genomics 12:60-60(2011).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is IV (CC-C-C-C-C).
CC -!- PTM: Contains 3 disulfide bonds (By similarity). They are not indicated
CC here, since framework IV presents two different connectivities (I-V,
CC II-III, IV-VI and I-III, II-V, IV-VI). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0CY79; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR009958; Conotoxin_a-typ.
DR Pfam; PF07365; Toxin_8; 1.
PE 2: Evidence at transcript level;
KW Amidation; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Secreted; Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..44
FT /evidence="ECO:0000250"
FT /id="PRO_0000409973"
FT PEPTIDE 45..70
FT /note="Conotoxin Bu24"
FT /id="PRO_0000409974"
FT MOD_RES 70
FT /note="Asparagine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 71 AA; 7825 MW; 8CC8F6D9A8EFDD4A CRC64;
MGMRMMVTVF LLVVLATTVV SLRSNRASDG RRGIVNKLND LVPKYWTECC GRIGPHCSRC
ICPEVACPKN G