ID   CA426_CONBU             Reviewed;          59 AA.
AC   P0CY81;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Conotoxin Bu26;
DE   Flags: Precursor; Fragment;
OS   Conus bullatus (Bubble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Textilia.
OX   NCBI_TaxID=89438;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=21266071; DOI=10.1186/1471-2164-12-60;
RA   Hu H., Bandyopadhyay P.K., Olivera B.M., Yandell M.;
RT   "Characterization of the Conus bullatus genome and its venom-duct
RT   transcriptome.";
RL   BMC Genomics 12:60-60(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is IV (CC-C-C-C-C).
CC   -!- PTM: Contains 3 disulfide bonds (By similarity). They are not indicated
CC       here, since framework IV presents two different connectivities (I-V,
CC       II-III, IV-VI and I-III, II-V, IV-VI). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CY81; -.
DR   SMR; P0CY81; -.
DR   TCDB; 8.B.32.2.2; the nicotinic acetylcholine receptor-targeting alpha-conotoxin (a-conotoxin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009958; Conotoxin_a-typ.
DR   Pfam; PF07365; Toxin_8; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          <1..10
FT                   /evidence="ECO:0000255"
FT   PROPEP          11..37
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000409977"
FT   PEPTIDE         38..59
FT                   /note="Conotoxin Bu26"
FT                   /id="PRO_0000409978"
FT   NON_TER         1
SQ   SEQUENCE   59 AA;  6569 MW;  18CE19A9404E8DD4 CRC64;
     LVVLATTVVS FRSNRASDGR KIAVNKRRRE LVVPPGKLRE CCGRVGPMCP KCMCPPRRC