CA427_CONBU
ID CA427_CONBU Reviewed; 53 AA.
AC P0CY82;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 22.
DE RecName: Full=Kappa-conotoxin-like Bu27;
DE Flags: Precursor; Fragment;
OS Conus bullatus (Bubble cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Textilia.
OX NCBI_TaxID=89438;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=21266071; DOI=10.1186/1471-2164-12-60;
RA Hu H., Bandyopadhyay P.K., Olivera B.M., Yandell M.;
RT "Characterization of the Conus bullatus genome and its venom-duct
RT transcriptome.";
RL BMC Genomics 12:60-60(2011).
CC -!- FUNCTION: Kappa-conotoxins bind and inhibit voltage-gated potassium
CC channels. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is IV (CC-C-C-C-C).
CC -!- PTM: Contains 3 disulfide bonds (By similarity). They are not indicated
CC here, since framework IV presents two different connectivities (I-V,
CC II-III, IV-VI and I-III, II-V, IV-VI). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0CY82; -.
DR SMR; P0CY82; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR009958; Conotoxin_a-typ.
DR Pfam; PF07365; Toxin_8; 1.
PE 2: Evidence at transcript level;
KW Amidation; Disulfide bond; Gamma-carboxyglutamic acid; Hydroxylation;
KW Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW Secreted; Toxin.
FT PROPEP <1..12
FT /evidence="ECO:0000250"
FT /id="PRO_0000409979"
FT PEPTIDE 13..48
FT /note="Kappa-conotoxin-like Bu27"
FT /id="PRO_0000409980"
FT PROPEP 49..53
FT /evidence="ECO:0000250"
FT /id="PRO_0000409981"
FT MOD_RES 14
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 15
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000250"
FT MOD_RES 29
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 34
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 35
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 43
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 44
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 48
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 48
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT NON_TER 1
SQ SEQUENCE 53 AA; 5745 MW; 51299FA61D1EE0C2 CRC64;
ASDGRNAVVH ERAPELVVTA TTTCCGYDPM TICPPCMCTH SCPPKRKPGR RND
