CA42_CONAH
ID CA42_CONAH Reviewed; 41 AA.
AC A3DT44;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Kappa-conotoxin Ac4.2;
DE Flags: Precursor; Fragment;
OS Conus achatinus (Little frog cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX NCBI_TaxID=369967;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17400270; DOI=10.1016/j.toxicon.2007.02.011;
RA Yuan D.-D., Han Y.-H., Wang C.-G., Chi C.-W.;
RT "From the identification of gene organization of alpha conotoxins to the
RT cloning of novel toxins.";
RL Toxicon 49:1135-1149(2007).
CC -!- FUNCTION: Kappa-conotoxins bind and inhibit voltage-gated potassium
CC channels. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is IV (CC-C-C-C-C).
CC -!- PTM: Contains 3 disulfide bonds (By similarity). They are not added,
CC since framework IV presents two different connectivities (I-V, II-III,
CC IV-VI and I-III, II-V, IV-VI). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR EMBL; DQ311073; ABD33865.1; -; Genomic_DNA.
DR AlphaFoldDB; A3DT44; -.
DR SMR; A3DT44; -.
DR TCDB; 8.B.32.2.1; the nicotinic acetylcholine receptor-targeting alpha-conotoxin (a-conotoxin) family.
DR ConoServer; 563; Ac4.2 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR009958; Conotoxin_a-typ.
DR Pfam; PF07365; Toxin_8; 1.
PE 3: Inferred from homology;
KW Amidation; Disulfide bond; Glycoprotein; Hydroxylation;
KW Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW Secreted; Toxin.
FT PROPEP <1..11
FT /evidence="ECO:0000250"
FT /id="PRO_0000370642"
FT PEPTIDE 12..40
FT /note="Kappa-conotoxin Ac4.2"
FT /id="PRO_0000370643"
FT MOD_RES 13
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 33
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 40
FT /note="Cysteine amide"
FT /evidence="ECO:0000250"
FT CARBOHYD 18
FT /note="O-linked (HexNAc...) threonine"
FT /evidence="ECO:0000250"
FT CARBOHYD 20
FT /note="O-linked (HexNAc...) threonine"
FT /evidence="ECO:0000250"
FT NON_TER 1
SQ SEQUENCE 41 AA; 4307 MW; 2F2E6FD405551713 CRC64;
FDGRNAAVNE RAPWMVVTAT TNCCGYTGPA CHPCLCTQSC G