ID   CA43A_CONAH             Reviewed;          52 AA.
AC   P0CAQ2; A3DT45; A3DT46;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Kappa-conotoxin-like Ac4.3a;
DE   Flags: Precursor; Fragment;
OS   Conus achatinus (Little frog cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=369967;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17400270; DOI=10.1016/j.toxicon.2007.02.011;
RA   Yuan D.-D., Han Y.-H., Wang C.-G., Chi C.-W.;
RT   "From the identification of gene organization of alpha conotoxins to the
RT   cloning of novel toxins.";
RL   Toxicon 49:1135-1149(2007).
CC   -!- FUNCTION: Kappa-conotoxins bind and inhibit voltage-gated potassium
CC       channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is IV (CC-C-C-C-C).
CC   -!- PTM: Contains 3 disulfide bonds (By similarity). They are not added,
CC       since framework IV presents two different connectivities (I-V, II-III,
CC       IV-VI and I-III, II-V, IV-VI). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   EMBL; DQ311074; ABD33866.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0CAQ2; -.
DR   SMR; P0CAQ2; -.
DR   TCDB; 8.B.32.2.3; the nicotinic acetylcholine receptor-targeting alpha-conotoxin (a-conotoxin) family.
DR   ConoServer; 564; Ac4.3a precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009958; Conotoxin_a-typ.
DR   Pfam; PF07365; Toxin_8; 1.
PE   3: Inferred from homology;
KW   Amidation; Disulfide bond; Gamma-carboxyglutamic acid; Hydroxylation;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Pyrrolidone carboxylic acid; Secreted; Toxin.
FT   PROPEP          <1..11
FT                   /id="PRO_0000370644"
FT   PEPTIDE         12..47
FT                   /note="Kappa-conotoxin-like Ac4.3a"
FT                   /id="PRO_0000370645"
FT   PROPEP          48..52
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000370646"
FT   MOD_RES         12
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         14
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         28
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         33
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         47
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         47
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   52 AA;  5840 MW;  17CDC2D7E1003B0A CRC64;
     SDFRNAAVHE RQKELVVTAT TTCCGYNPMT SCPRCMCDSS CNKKKKPGRR ND