CA4B_CONSE
ID CA4B_CONSE Reviewed; 80 AA.
AC P0CE76; P0C1Y3;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 1.
DT 25-MAY-2022, entry version 27.
DE RecName: Full=Kappa-conotoxin-like SmIVB;
DE Flags: Precursor;
OS Conus stercusmuscarum (Fly-specked cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX NCBI_TaxID=89452;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=14701840; DOI=10.1074/jbc.m309654200;
RA Santos A.D., McIntosh J.M., Hillyard D.R., Cruz L.J., Olivera B.M.;
RT "The A-superfamily of conotoxins: structural and functional divergence.";
RL J. Biol. Chem. 279:17596-17606(2004).
CC -!- FUNCTION: Kappa-A-conotoxins bind and inhibit voltage-gated potassium
CC channels. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is IV (CC-C-C-C-C).
CC -!- PTM: Contains 3 disulfide bonds (By similarity). They are not added,
CC since framework IV presents two different connectivities (I-V, II-III,
CC IV-VI and I-III, II-V, IV-VI). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0CE76; -.
DR SMR; P0CE76; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR009958; Conotoxin_a-typ.
DR Pfam; PF07365; Toxin_8; 1.
PE 2: Evidence at transcript level;
KW Amidation; Disulfide bond; Glycoprotein; Hydroxylation;
KW Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW Secreted; Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..38
FT /evidence="ECO:0000250"
FT /id="PRO_0000392709"
FT PEPTIDE 39..75
FT /note="Kappa-conotoxin-like SmIVB"
FT /id="PRO_0000392710"
FT PROPEP 76..80
FT /evidence="ECO:0000250"
FT /id="PRO_0000392711"
FT MOD_RES 40
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 55
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 60
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 61
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 70
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 72
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 75
FT /note="Serine amide"
FT /evidence="ECO:0000250"
FT CARBOHYD 45
FT /note="O-linked (HexNAc...) serine"
FT /evidence="ECO:0000305"
FT CARBOHYD 46
FT /note="O-linked (HexNAc...) threonine"
FT /evidence="ECO:0000305"
SQ SEQUENCE 80 AA; 8778 MW; 5FE60549491A0203 CRC64;
MGMRMMFTVF LLVVLATTVV SIPSDRASDG RNAEVNERAP WLVPSTITTC CGYDPGSMCP
PCMCNNTCKP KPKKSGRRNH