ID   UPPP_HALMA              Reviewed;         270 AA.
AC   Q5UXT1;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Undecaprenyl-diphosphatase;
DE            EC=3.6.1.27;
DE   AltName: Full=Undecaprenyl pyrophosphate phosphatase;
GN   Name=uppP; Synonyms=bacA; OrderedLocusNames=rrnAC3219;
OS   Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS   B-1809) (Halobacterium marismortui).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=272569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX   PubMed=15520287; DOI=10.1101/gr.2700304;
RA   Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA   Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA   Hood L., Ng W.V.;
RT   "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT   Dead Sea.";
RL   Genome Res. 14:2221-2234(2004).
CC   -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl diphosphate
CC       (UPP). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-
CC         trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate;
CC         Xref=Rhea:RHEA:28094, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58405, ChEBI:CHEBI:60392; EC=3.6.1.27;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UppP family. {ECO:0000305}.
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DR   EMBL; AY596297; AAV47922.1; -; Genomic_DNA.
DR   RefSeq; WP_007189186.1; NZ_CP039138.1.
DR   AlphaFoldDB; Q5UXT1; -.
DR   SMR; Q5UXT1; -.
DR   STRING; 272569.rrnAC3219; -.
DR   EnsemblBacteria; AAV47922; AAV47922; rrnAC3219.
DR   GeneID; 40154022; -.
DR   KEGG; hma:rrnAC3219; -.
DR   PATRIC; fig|272569.17.peg.3756; -.
DR   eggNOG; arCOG04761; Archaea.
DR   HOGENOM; CLU_060296_1_2_2; -.
DR   OMA; IEGPFRD; -.
DR   Proteomes; UP000001169; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050380; F:undecaprenyl-diphosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   InterPro; IPR003824; UppP.
DR   PANTHER; PTHR30622; PTHR30622; 1.
DR   Pfam; PF02673; BacA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..270
FT                   /note="Undecaprenyl-diphosphatase"
FT                   /id="PRO_0000151249"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   270 AA;  27661 MW;  561FB4E3D0D7DB83 CRC64;
     MNPILVAILL GLLQGVLEWI PVSSEGGVAL ASTVVTGVSP AASTRLALFL HAGTAVAATA
     YYRTEVRTIL HSIRQLSRRP FADETADLSF IVIATAATAV TGLPAYMVLD AAVSELEGGL
     FLALVGGLLV ITGLLQRFAA ALSLGEREIP DGFDAVLVGV LQGLAILPGV SRSGTTVSAL
     LLRGHEGESS LRLSFLLSIP AALAANVLVL VDDGIPAIEP LPAVVALIVS AVVGYLTVDA
     LVRLVRQVPF WAVCTVFGGL GVVGGLLVAL