ID   CA4E_CONPU              Reviewed;          24 AA.
AC   P0C2C5;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Conotoxin PIVE;
DE   AltName: Full=Kappa-A-conotoxin PIVE;
DE            Short=KappaA-PIVE;
OS   Conus purpurascens (Purple cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Chelyconus.
OX   NCBI_TaxID=41690;
RN   [1]
RP   PROTEIN SEQUENCE, SYNTHESIS, FUNCTION, DISULFIDE BONDS, AMIDATION AT
RP   LYS-24, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=17118419; DOI=10.1016/j.toxicon.2006.10.001;
RA   Teichert R.W., Jacobsen R., Terlau H., Yoshikami D., Olivera B.M.;
RT   "Discovery and characterization of the short kappaA-conotoxins: a novel
RT   subfamily of excitatory conotoxins.";
RL   Toxicon 49:318-328(2007).
CC   -!- FUNCTION: This toxin elicits dose-dependently excitatory activity upon
CC       injection into fish. Its action is slowly reversible. Does not have any
CC       direct effects on neuromuscular nAChRs (human adult alpha-1/beta-
CC       1/epsilon/delta or fetal alpha-1/beta-1/gamma/delta receptors). Does
CC       not have any effects on human Kv1 (KCNA1, KCNA2, KCNA3, KCNA4, KCNA5,
CC       and KCNA), Kv2.1/KCNB1, Kv3.4 (KCNC4), Kv4.2 (KCND2), KCNQ2/3, and on
CC       the Drosophilia Shaker potassium channels. Does not have effects on the
CC       fish potassium channels, TSha1, TSha2 (Kv1 homologs), and Traw (Kv3
CC       homolog), without detectable activity. {ECO:0000269|PubMed:17118419}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is IV (CC-C-C-C-C).
CC   -!- MASS SPECTROMETRY: Mass=2656; Method=LSI;
CC       Evidence={ECO:0000269|PubMed:17118419};
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C2C5; -.
DR   TCDB; 8.B.32.2.5; the nicotinic acetylcholine receptor-targeting alpha-conotoxin (a-conotoxin) family.
DR   ConoServer; 1670; PIVE.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted;
KW   Toxin.
FT   PEPTIDE         1..24
FT                   /note="Conotoxin PIVE"
FT                   /id="PRO_0000273427"
FT   MOD_RES         24
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000269|PubMed:17118419"
FT   DISULFID        2..10
FT                   /evidence="ECO:0000269|PubMed:17118419"
FT   DISULFID        3..15
FT                   /evidence="ECO:0000269|PubMed:17118419"
FT   DISULFID        13..19
FT                   /evidence="ECO:0000269|PubMed:17118419"
SQ   SEQUENCE   24 AA;  2664 MW;  671F1A3F5AFD0A34 CRC64;
     DCCGVKLEMC HPCLCDNSCK NYGK