ID   CA4F_CONPU              Reviewed;          24 AA.
AC   P0C2C6;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Kappa-conotoxin-like PIVF;
DE            Short=KappaA-PIVF;
OS   Conus purpurascens (Purple cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Chelyconus.
OX   NCBI_TaxID=41690;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT LYS-24.
RC   TISSUE=Venom;
RX   PubMed=17118419; DOI=10.1016/j.toxicon.2006.10.001;
RA   Teichert R.W., Jacobsen R., Terlau H., Yoshikami D., Olivera B.M.;
RT   "Discovery and characterization of the short kappaA-conotoxins: a novel
RT   subfamily of excitatory conotoxins.";
RL   Toxicon 49:318-328(2007).
CC   -!- FUNCTION: Kappa-conotoxins bind and inhibit voltage-gated potassium
CC       channels (By similarity). Elicits excitatory activity upon injection
CC       into fish. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is IV (CC-C-C-C-C).
CC   -!- PTM: Contains 3 disulfide bonds (By similarity). They are not added,
CC       since framework IV presents two different connectivities (I-V, II-III,
CC       IV-VI and I-III, II-V, IV-VI). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C2C6; -.
DR   ConoServer; 1669; PIVF.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Toxin.
FT   PEPTIDE         1..24
FT                   /note="Kappa-conotoxin-like PIVF"
FT                   /id="PRO_0000273428"
FT   MOD_RES         24
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000269|PubMed:17118419"
SQ   SEQUENCE   24 AA;  2602 MW;  671F14D82AFD0A34 CRC64;
     DCCGVKLEMC HPCLCDNSCK KSGK