CA761_CONIN
ID CA761_CONIN Reviewed; 17 AA.
AC P0DUR2;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 1.
DT 23-FEB-2022, entry version 2.
DE RecName: Full=Alpha-conotoxin In1761 {ECO:0000303|PubMed:33732044};
OS Conus inscriptus (Engraved cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
OX NCBI_TaxID=257329;
RN [1]
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, HYDROXYLATION AT
RP PRO-7, AND AMIDATION AT GLY-17.
RC TISSUE=Venom;
RX PubMed=33732044; DOI=10.1016/j.sjbs.2020.12.032;
RA Jain R.P., Jayaseelan B.F., Wilson Alphonse C.R., Mahmoud A.H.,
RA Mohammed O.B., Ahmed Almunqedhi B.M., Rajaian Pushpabai R.;
RT "Mass spectrometric identification and denovo sequencing of novel
RT conotoxins from vermivorous cone snail (Conus inscriptus), and preliminary
RT screening of its venom for biological activities in vitro and in vivo.";
RL Saudi J. Biol. Sci. 28:1582-1595(2021).
CC -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
CC {ECO:0000250|UniProtKB:P0C1R7}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33732044}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:33732044}.
CC -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/7 pattern.
CC {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=1761.7; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:33732044};
CC -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR009958; Conotoxin_a-typ.
DR InterPro; IPR018072; Conotoxin_a-typ_CS.
DR Pfam; PF07365; Toxin_8; 1.
PE 1: Evidence at protein level;
KW Acetylcholine receptor inhibiting toxin; Amidation;
KW Direct protein sequencing; Disulfide bond; Hydroxylation;
KW Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW Toxin.
FT PEPTIDE 1..17
FT /note="Alpha-conotoxin In1761"
FT /evidence="ECO:0000269|PubMed:33732044"
FT /id="PRO_0000453224"
FT REGION 4..6
FT /note="Ser-Xaa-Pro motif, crucial for potent interaction
FT with nAChR"
FT /evidence="ECO:0000250|UniProtKB:P56636"
FT MOD_RES 7
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:33732044"
FT MOD_RES 17
FT /note="Glycine amide"
FT /evidence="ECO:0000269|PubMed:33732044"
FT DISULFID 2..8
FT /evidence="ECO:0000250|UniProtKB:P0C1R7"
FT DISULFID 3..16
FT /evidence="ECO:0000250|UniProtKB:P0C1R7"
SQ SEQUENCE 17 AA; 1752 MW; 78962A04BC4AC98F CRC64;
GCCSHPPCNV NNPHICG