ID   CAAP1_BOVIN             Reviewed;         362 AA.
AC   Q2T9W9;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Caspase activity and apoptosis inhibitor 1;
DE   AltName: Full=Conserved anti-apoptotic protein;
DE            Short=CAAP;
GN   Name=CAAP1; Synonyms=CAAP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Anti-apoptotic protein that modulates a caspase-10 dependent
CC       mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000250}.
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DR   EMBL; BC111229; AAI11230.1; -; mRNA.
DR   RefSeq; NP_001033209.1; NM_001038120.1.
DR   AlphaFoldDB; Q2T9W9; -.
DR   STRING; 9913.ENSBTAP00000001617; -.
DR   PaxDb; Q2T9W9; -.
DR   PRIDE; Q2T9W9; -.
DR   Ensembl; ENSBTAT00000001617; ENSBTAP00000001617; ENSBTAG00000001223.
DR   GeneID; 515858; -.
DR   KEGG; bta:515858; -.
DR   CTD; 79886; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001223; -.
DR   VGNC; VGNC:26660; CAAP1.
DR   eggNOG; ENOG502RN9N; Eukaryota.
DR   GeneTree; ENSGT00390000017010; -.
DR   HOGENOM; CLU_078683_0_0_1; -.
DR   InParanoid; Q2T9W9; -.
DR   OMA; CQPSIQQ; -.
DR   OrthoDB; 1443498at2759; -.
DR   TreeFam; TF332850; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000001223; Expressed in occipital lobe and 106 other tissues.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:2001268; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR038991; CAAP1.
DR   PANTHER; PTHR14740; PTHR14740; 1.
DR   Pfam; PF15335; CAAP1; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Coiled coil; Isopeptide bond; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..362
FT                   /note="Caspase activity and apoptosis inhibitor 1"
FT                   /id="PRO_0000285783"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          65..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          282..312
FT                   /evidence="ECO:0000255"
FT   MOD_RES         89
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8G2"
FT   MOD_RES         90
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8G2"
FT   MOD_RES         121
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8G2"
FT   MOD_RES         204
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8G2"
FT   MOD_RES         313
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8G2"
FT   CROSSLNK        105
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8G2"
SQ   SEQUENCE   362 AA;  38487 MW;  970BD4C622FDB3F1 CRC64;
     MTGKKSSREK RRKRSGQEAA AALAAPDLVP AVGGSGSGST SGCGSASGCG SVTCCGNTSV
     SGSVTGGGSG GSCWGGSSVE RGERRKRRST DSSSSVSGSL QQEAKYLLPP LEKELFLAEH
     SDLEEGGLDL TVALKPVSFY ISDKKEMLRQ CFCIIGEKKL QKMLPDVLKN CSIEEIKRLC
     QEQLELLSEK KILKILEGDN GMDSEMEEEA DDGSKMVSDV VNQQDSCVDS TSSLRENKQP
     EGLELKQGKG EDSDVLSINA DAYDSDIEGP CNEEAAAPEV PENTVQSEAG QIDDLEKDIE
     KSVNEILGLA ESSPKEPKAA TLTVPPPEDV QPSAQQLELL ELEMRARAIK ALMKAGDIKK
     PA