CAAT3_ARATH
ID CAAT3_ARATH Reviewed; 609 AA.
AC Q8GYB4; Q9FIV7;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Cationic amino acid transporter 3, mitochondrial;
DE Flags: Precursor;
GN Name=CAT3; OrderedLocusNames=At5g36940; ORFNames=MLF18.60;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=15377779; DOI=10.1104/pp.104.045278;
RA Su Y.-H., Frommer W.B., Ludewig U.;
RT "Molecular and functional characterization of a family of amino acid
RT transporters from Arabidopsis.";
RL Plant Physiol. 136:3104-3113(2004).
CC -!- FUNCTION: Permease involved in the transport of the cationic neutral or
CC acidic amino acids. {ECO:0000269|PubMed:15377779}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems, flowers, and leaves.
CC {ECO:0000269|PubMed:15377779}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11637.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB016877; BAB11637.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED94130.1; -; Genomic_DNA.
DR EMBL; AK117747; BAC42395.1; -; mRNA.
DR RefSeq; NP_198510.2; NM_123052.5.
DR AlphaFoldDB; Q8GYB4; -.
DR SMR; Q8GYB4; -.
DR STRING; 3702.AT5G36940.1; -.
DR PaxDb; Q8GYB4; -.
DR PRIDE; Q8GYB4; -.
DR ProteomicsDB; 240308; -.
DR EnsemblPlants; AT5G36940.1; AT5G36940.1; AT5G36940.
DR GeneID; 833664; -.
DR Gramene; AT5G36940.1; AT5G36940.1; AT5G36940.
DR KEGG; ath:AT5G36940; -.
DR Araport; AT5G36940; -.
DR TAIR; locus:2167462; AT5G36940.
DR eggNOG; KOG1286; Eukaryota.
DR HOGENOM; CLU_007946_15_7_1; -.
DR InParanoid; Q8GYB4; -.
DR OMA; GWSMIMD; -.
DR OrthoDB; 439017at2759; -.
DR PhylomeDB; Q8GYB4; -.
DR PRO; PR:Q8GYB4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8GYB4; baseline and differential.
DR Genevisible; Q8GYB4; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005635; C:nuclear envelope; IDA:TAIR.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR029485; CAT_C.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Mitochondrion; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..14
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 15..609
FT /note="Cationic amino acid transporter 3, mitochondrial"
FT /id="PRO_0000415779"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 534..554
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 558..578
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 609 AA; 65285 MW; 44006F19FD4F7973 CRC64;
MGCLRSLVRR KQFDSSNGKA ETHHHHQQLA KALTFPHLIA IGVGSTIGAG VYILVGTVAR
EHSGPALALS FLIAGISAAL SAFCYAELSS RFPSAGSAYH YSYICIGEGV AWLIGWALIL
EYTIGGSTVA RGISPNLAMI FGGEDCLPTI LARHQIPGLD IVVDPCAAVL VFIVTGLCCL
GVKESTFAQG IVTTANVFVM IFVIVAGSYL CFKTGWVGYE LPTGYFPYGV DGMLTGSATV
FFAYIGFDTV ASMAEEVKNP RRDLPLGIGI SLLLCCLLYM MVSVVIVGLV PYYAMDPDTP
ISSAFSSHGI QWAAYLINLG AVMALCSALM GSILPQPRIL MAMARDGLLP SYFSYVNQRT
QVPINGTITT GVCAAILAFF MDVSQLAGMV SVGTLVAFTM VAISLLIVRY VVPPDEVPLP
SSLQENSSSH VGTSIRSKQP LLGKVDDSVV DKENAPGSWV LNKKNRRKFA GWSIMFTCIG
NFLLSYAASS FLLPGLLRYS LCGVGGLFLL VGLIVLICID QDDARHSFGH SGGFICPFVP
LLPIVCILIN MYLLVNLGAA TWVRVSVWLF LGVVVYIFYG RRNSSLVNAV YVSTAHLQEI
RRTSGHSLA
