ID   CAB1_CAEEL              Reviewed;         425 AA.
AC   Q93249; P90751;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 3.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Protein cab-1;
GN   Name=cab-1; ORFNames=C23H4.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH AEX-3.
RC   STRAIN=Bristol N2;
RX   PubMed=10970871; DOI=10.1093/emboj/19.17.4806;
RA   Iwasaki K., Toyonaga R.;
RT   "The rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in
RT   synaptic transmission.";
RL   EMBO J. 19:4806-4816(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBUNIT: Binds to the RAB3 GDP/GTP exchange factor aex-3.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of neurons.
CC   -!- SIMILARITY: Belongs to the NPDC1/cab-1 family. {ECO:0000305}.
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DR   EMBL; AF293976; AAG17881.1; -; mRNA.
DR   EMBL; Z78416; CAB01682.1; -; Genomic_DNA.
DR   PIR; T19415; T19415.
DR   RefSeq; NP_510036.1; NM_077635.4.
DR   AlphaFoldDB; Q93249; -.
DR   BioGRID; 46288; 3.
DR   IntAct; Q93249; 1.
DR   STRING; 6239.C23H4.1.1; -.
DR   EPD; Q93249; -.
DR   PaxDb; Q93249; -.
DR   PeptideAtlas; Q93249; -.
DR   EnsemblMetazoa; C23H4.1.1; C23H4.1.1; WBGene00000277.
DR   EnsemblMetazoa; C23H4.1.2; C23H4.1.2; WBGene00000277.
DR   GeneID; 181382; -.
DR   KEGG; cel:CELE_C23H4.1; -.
DR   UCSC; C23H4.1.2; c. elegans.
DR   CTD; 181382; -.
DR   WormBase; C23H4.1; CE17435; WBGene00000277; cab-1.
DR   eggNOG; KOG3884; Eukaryota.
DR   GeneTree; ENSGT00440000038604; -.
DR   HOGENOM; CLU_638179_0_0_1; -.
DR   InParanoid; Q93249; -.
DR   OMA; PDDGEYA; -.
DR   OrthoDB; 1100151at2759; -.
DR   PRO; PR:Q93249; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00000277; Expressed in larva and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0007268; P:chemical synaptic transmission; IMP:WormBase.
DR   GO; GO:1905488; P:positive regulation of anterior/posterior axon guidance; IGI:UniProtKB.
DR   GO; GO:0007419; P:ventral cord development; IGI:UniProtKB.
DR   InterPro; IPR009635; NPDC1.
DR   PANTHER; PTHR23352; PTHR23352; 1.
DR   Pfam; PF06809; NPDC1; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..425
FT                   /note="Protein cab-1"
FT                   /id="PRO_0000089267"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          205..424
FT                   /note="AEX-3-binding"
FT   REGION          214..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   425 AA;  47224 MW;  6CC2C50AEEB7A1FA CRC64;
     MRYTFSDEKK ATTTTTSRAK SQARLLNSAS YRRAARTTLR HSYGMGMWRA VALLACLSAT
     HAALFTEGGA VQNGKDNKAN KYVEFAHDDK INKEDLLKYY GKEVEQYKDD DSYMEYLIEY
     MKSHPVPAQF PNFEQEAEQE HQDELNQWLE QLMNEQELLE PANAAVKDAE QKAPLAPVHH
     KQVAQKPAQE PFDLDDLLRG ELMLENEIAK ESELKKTQEK LSEQTPSAKA NVESLESAMQ
     TATGEPQVPQ KKGQNEFVSF VEQEPQPAKQ TISSQTVDKR RLATSAEYSG SAPRYSSSSL
     LLLAVGTVMC VGLIGTVAGG TYYYKNNRRT ETPDDGEYAP YAGTGPGFRK NKGNKGDETL
     AYKAQLHQYQ QAKQKIICGE DAPGIIESDG EDGADEENNY SVYECPGLAP TGDIEVCNPN
     FAAQP