ID   CAB39_BOVIN             Reviewed;         341 AA.
AC   Q29RI6;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Calcium-binding protein 39;
DE   AltName: Full=MO25alpha;
DE   AltName: Full=Protein Mo25;
GN   Name=CAB39;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a complex that binds and activates STK11/LKB1.
CC       In the complex, required to stabilize the interaction between
CC       CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a trimeric complex composed of STK11/LKB1, STRAD
CC       (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta):
CC       the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
CC       catalytic activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mo25 family. {ECO:0000305}.
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DR   EMBL; BC114154; AAI14155.1; -; mRNA.
DR   RefSeq; NP_001039552.1; NM_001046087.2.
DR   AlphaFoldDB; Q29RI6; -.
DR   SMR; Q29RI6; -.
DR   STRING; 9913.ENSBTAP00000052156; -.
DR   PaxDb; Q29RI6; -.
DR   PRIDE; Q29RI6; -.
DR   Ensembl; ENSBTAT00000053463; ENSBTAP00000052156; ENSBTAG00000040055.
DR   GeneID; 511451; -.
DR   KEGG; bta:511451; -.
DR   CTD; 51719; -.
DR   VEuPathDB; HostDB:ENSBTAG00000040055; -.
DR   VGNC; VGNC:26661; CAB39.
DR   eggNOG; KOG1566; Eukaryota.
DR   GeneTree; ENSGT00390000004360; -.
DR   HOGENOM; CLU_035755_0_0_1; -.
DR   InParanoid; Q29RI6; -.
DR   OMA; HLKLCMN; -.
DR   OrthoDB; 865327at2759; -.
DR   TreeFam; TF314910; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000040055; Expressed in gluteal muscle and 104 other tissues.
DR   ExpressionAtlas; Q29RI6; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030295; F:protein kinase activator activity; ISS:UniProtKB.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013878; Mo25.
DR   PANTHER; PTHR10182; PTHR10182; 1.
DR   Pfam; PF08569; Mo25; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..341
FT                   /note="Calcium-binding protein 39"
FT                   /id="PRO_0000244879"
SQ   SEQUENCE   341 AA;  39869 MW;  EC710A528B6F9811 CRC64;
     MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM KEILYGTNEK
     EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ IFNNILRRQI GTRTPTVEYI
     CTQQNILFML LKGYESPEIA LNCGIMLREC IRHEPLAKII LWSEQFYDFF RYVEMSTFDI
     ASDAFATFKD LLTRHKLLSA EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR
     HNFTIMTKYI SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA
     KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A