CABIN_ARATH
ID CABIN_ARATH Reviewed; 1863 AA.
AC F4JV59; Q9M078;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Calcineurin-binding protein 1 {ECO:0000303|PubMed:25086063, ECO:0000303|PubMed:25600486};
DE Short=AtCABIN1 {ECO:0000303|PubMed:25086063};
GN Name=CABIN1 {ECO:0000303|PubMed:25086063, ECO:0000303|PubMed:25600486};
GN OrderedLocusNames=At4g32820 {ECO:0000312|Araport:AT4G32820};
GN ORFNames=T16I18.30 {ECO:0000312|EMBL:CAB79999.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP DISRUPTION PHENOTYPE, SUBUNIT, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=25086063; DOI=10.1242/bio.20148680;
RA Nie X., Wang H., Li J., Holec S., Berger F.;
RT "The HIRA complex that deposits the histone H3.3 is conserved in
RT Arabidopsis and facilitates transcriptional dynamics.";
RL Biol. Open 3:794-802(2014).
RN [4]
RP SUBUNIT, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=25600486; DOI=10.1111/tpj.12758;
RA Duc C., Benoit M., Le Goff S., Simon L., Poulet A., Cotterell S.,
RA Tatout C., Probst A.V.;
RT "The histone chaperone complex HIR maintains nucleosome occupancy and
RT counterbalances impaired histone deposition in CAF-1 complex mutants.";
RL Plant J. 81:707-722(2015).
CC -!- FUNCTION: May be required for replication-independent chromatin
CC assembly. {ECO:0000250|UniProtKB:Q9Y6J0}.
CC -!- SUBUNIT: Component of the HIRA complex made of UBN1, UBN2, ASF1A,
CC CABIN1 and HIRA. {ECO:0000269|PubMed:25086063,
CC ECO:0000269|PubMed:25600486}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in seedlings.
CC {ECO:0000269|PubMed:25600486}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype (PubMed:25086063,
CC PubMed:25600486). The double mutant hira-1 cabin1-2 has aborted and
CC fewer viable seeds (PubMed:25600486). {ECO:0000269|PubMed:25086063,
CC ECO:0000269|PubMed:25600486}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB79999.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL161582; CAB79999.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86122.1; -; Genomic_DNA.
DR PIR; T10689; T10689.
DR RefSeq; NP_195008.6; NM_119435.7.
DR AlphaFoldDB; F4JV59; -.
DR SMR; F4JV59; -.
DR STRING; 3702.AT4G32820.2; -.
DR iPTMnet; F4JV59; -.
DR PRIDE; F4JV59; -.
DR ProteomicsDB; 240540; -.
DR EnsemblPlants; AT4G32820.1; AT4G32820.1; AT4G32820.
DR GeneID; 829418; -.
DR Gramene; AT4G32820.1; AT4G32820.1; AT4G32820.
DR KEGG; ath:AT4G32820; -.
DR Araport; AT4G32820; -.
DR HOGENOM; CLU_002326_0_0_1; -.
DR PRO; PR:F4JV59; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JV59; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR033053; Hir3/CABIN1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15502; PTHR15502; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 1: Evidence at protein level;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1863
FT /note="Calcineurin-binding protein 1"
FT /id="PRO_0000444035"
FT REPEAT 30..65
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 81..116
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 118..150
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT REPEAT 543..576
FT /note="TPR 4"
FT /evidence="ECO:0000255"
FT REPEAT 602..637
FT /note="TPR 5"
FT /evidence="ECO:0000255"
FT REPEAT 866..900
FT /note="TPR 6"
FT /evidence="ECO:0000255"
FT REPEAT 955..988
FT /note="TPR 7"
FT /evidence="ECO:0000255"
FT REPEAT 990..1009
FT /note="TPR 8"
FT /evidence="ECO:0000255"
FT REPEAT 1011..1031
FT /note="TPR 9"
FT /evidence="ECO:0000255"
FT REPEAT 1143..1183
FT /note="TPR 10"
FT /evidence="ECO:0000255"
FT REPEAT 1226..1263
FT /note="TPR 11"
FT /evidence="ECO:0000255"
FT REPEAT 1264..1297
FT /note="TPR 12"
FT /evidence="ECO:0000255"
FT REPEAT 1306..1339
FT /note="TPR 13"
FT /evidence="ECO:0000255"
FT REPEAT 1377..1412
FT /note="TPR 14"
FT /evidence="ECO:0000255"
FT REPEAT 1508..1541
FT /note="TPR 15"
FT /evidence="ECO:0000255"
FT REGION 315..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 894..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1813..1840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1815..1833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1863 AA; 210741 MW; 46336FC2BAEB0475 CRC64;
MFSIAAINDT ESTEKWEPLA PSKEAQEFHL SQTYHDGLLK LQAKDYDKAR ELLESILKDP
IITNSKVETI ANDNHLHHLR FLALKNLATV FLELGSSHYE NALNCYLQAI DLDAKDSVLW
NHLGTLSCSM GLLSISRWAF EQGLLCSPNN WNCMEKLLEV LIAVGDEVSC LSVANLILRH
WPSHSRALHV KHCIEDTDSA PFAPKGIDKL EPQHVRLKFL GKRKVSDMNQ DMDATSKKLR
KRVQFKLPEA SWVALLNILI GIVHPSRETV GISADIPITI ELSLSTEAVM QGMKKKDHCV
DSDSSNVSVK DCNIERESGG SVKEKEPVFS EEHPQERRST RLERLRNQKP EKEGLEFDNS
KDPSSDILQY LEKFVLKRGF DRESAGSFCN EESDPISEHA VVSNFVKENL ENYGAYHMGH
LLLEYIANKC EHVLSRETAL KILELEKLTR HWGRDRKPEC SLFLAELYHD FDSKRSDIPD
APSCMVEVTY HLSKIIESVS LDYAIDSTPS SRGKMFSDSS FKSFQGDEAA KEVLDYDTRS
FWARYFWLSA RLSILEDNKA KALEEYLRCL SLLGREGIGE APVLIQRPHC RRVRELTINR
IIHEINLLKI DFLLENNIPE MMEKEFYSEC VNLLAPLLFP DKDILPAYAV KTEEGISSVE
LSALEVLIKA CQKSKPIDVE VYMNCHRRKL QVLLDSTGTG ESVVTPKTSS KNSSESWDHL
VAEEVKAILL CISQVKNSLD QSGNSDDMVA PRDCVAGIQA LLLRVMSNIV RHFFSKRYSD
SQNADGIEEE KKSCFLDAAI GFCKLQHLDA TISTKYQVEL IIRLHDLLAE YGLCCAGKNC
AGEEGAFLRF AIKHLLAVDM KVKSSINSPD GLGHDMGLPD KLCRNEVKSF LEEVHVEKNE
NNKTESKKDG SEEQVGYREK EQSEQQSKQI PEHTEEVAEE EKDELELLIN NALDQCFFCL
YGLNLRVDGS YEDELAVHKN TSRGDYQTKE QCVDVFQYIL PYAKASSRTG LVKLRRVLRA
IKKHFSQPPD DLLIGNVIDK FLDDPELCED KLSYEAGSEG FLETITKCLI PSRTLSEYKI
SLLHSSDPYL DVYRNLYFLL AQSEEVSASD KWPGFVLTKE GEEFEQQNTN LFKYDLLYNP
LRFESWEKLG NIYDEEVDLL LNDGSKHINV VGWRKNSALS QRVETSRRRS RRCLLMSLAL
ANSPDQQSEI HELLALVYYD SLQSVVPFYD QRSVLPSKDA TWTRFCENSM KHFNKAFSHR
QDWSHAFYMG KLSEKLGHSY EISLSYYKQA MTLNPSAVDP VYRMHASRLK LLNACGKQNL
EALKVLASYC FDESIKDTAM TIIGTTTFGS SRTLEEAQDG NLEACYAKSG EGSIQMEGVW
HMLYNDSLSA LGICVEGDLK HFHKARYMLA QGLYRRGGSS DLQRAKEELS FCFKSSRSSF
TINMWEIDGM VKKGRRKTPG LAGNKKALEV NLPESSRKFI TCIRKYLLFY LRLLEETEDV
NTLERAFNSL RSDKRFSLCV EDLVPVAIGR YVKALVSSMS RVESAGAIIN PDSQLEKIFS
LFIEQGSIWP DICNFPETRG PETSESSLYR YLHQYIVSLE LDNKVETLET INEKIRKRFK
NPKLSNSFSA KVGRHASLAW CRALIISLAL ITPLQPVSSE ESQAITPSFG LLENRRVLCV
DLQSEFWSSS FEDPLESQML EAKWRPVLSK IKNVLIFNKV VEGNLEIANS LLKSCYNFFR
ETASVTLPSD INLYFALPRL APAGELLPGN EGVEVIDVSI PRKLLLWAYT LFHGHCGSIS
QVVKYMEENT KPKMKRGAST SSVVPSVQSG GTSEPEPAPK VVQVIIPDSL GGDSCGSTPA
APL
