ID   UPP_BOVIN               Reviewed;         306 AA.
AC   Q32LA4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Uracil phosphoribosyltransferase homolog;
GN   Name=UPRT;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPRTase family. {ECO:0000305}.
CC   -!- CAUTION: The uracil binding region known from UPRTases is missing.
CC       {ECO:0000305}.
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DR   EMBL; BC109679; AAI09680.1; -; mRNA.
DR   RefSeq; NP_001069713.1; NM_001076245.2.
DR   AlphaFoldDB; Q32LA4; -.
DR   SMR; Q32LA4; -.
DR   BioGRID; 197418; 1.
DR   STRING; 9913.ENSBTAP00000005978; -.
DR   PaxDb; Q32LA4; -.
DR   PRIDE; Q32LA4; -.
DR   GeneID; 540851; -.
DR   KEGG; bta:540851; -.
DR   CTD; 139596; -.
DR   eggNOG; KOG1017; Eukaryota.
DR   InParanoid; Q32LA4; -.
DR   OrthoDB; 929897at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   SUPFAM; SSF53271; SSF53271; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..306
FT                   /note="Uracil phosphoribosyltransferase homolog"
FT                   /id="PRO_0000254534"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          58..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         130
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         139
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         173..176
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         183
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         200
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         229
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         235..243
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         296..298
FT                   /ligand="uracil"
FT                   /ligand_id="ChEBI:CHEBI:17568"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
SQ   SEQUENCE   306 AA;  33355 MW;  BB03DA9466A7302C CRC64;
     MATELRCPDS MPCHNQQVNS ASTQNPEPQQ AGDLILAHAG GNSDSAATLT LLSGHAHSSV
     PAELDPQASG GATFNSENNG GTGNYDAPAS DSLLGDCEIS RQIGAQLKLL PMNDQIRELQ
     TIIRDKTASR GDFMFSADRL IRLVVEEGLN QLPYEECMVT TPTGFKYEGV KFEKGNCGVS
     IMRSGEAMEQ GLRDCCRSIR IGKILIQSDE ETQRAKVYYA KFPPDIYRRK VLLMYPILST
     GNTVIEAVKV LIEHGVQPSV IILLSLFSTP HGAKSIIQEF PEITILTTEV HPVAPTHFGQ
     KYFGTD