ID   UPP_CHICK               Reviewed;         277 AA.
AC   Q5ZIJ8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Uracil phosphoribosyltransferase homolog;
GN   Name=UPRT; ORFNames=RCJMB04_25k2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPRTase family. {ECO:0000305}.
CC   -!- CAUTION: The uracil binding region known from UPRTases is missing.
CC       {ECO:0000305}.
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DR   EMBL; AJ720786; CAG32445.1; -; mRNA.
DR   RefSeq; NP_001026295.1; NM_001031124.1.
DR   AlphaFoldDB; Q5ZIJ8; -.
DR   SMR; Q5ZIJ8; -.
DR   STRING; 9031.ENSGALP00000012624; -.
DR   PaxDb; Q5ZIJ8; -.
DR   GeneID; 422327; -.
DR   KEGG; gga:422327; -.
DR   CTD; 139596; -.
DR   VEuPathDB; HostDB:geneid_422327; -.
DR   eggNOG; KOG1017; Eukaryota.
DR   InParanoid; Q5ZIJ8; -.
DR   OrthoDB; 929897at2759; -.
DR   PhylomeDB; Q5ZIJ8; -.
DR   PRO; PR:Q5ZIJ8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   SUPFAM; SSF53271; SSF53271; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..277
FT                   /note="Uracil phosphoribosyltransferase homolog"
FT                   /id="PRO_0000254537"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         101
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         110
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         144..147
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         154
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         171
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         200
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         206..214
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         267..269
FT                   /ligand="uracil"
FT                   /ligand_id="ChEBI:CHEBI:17568"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
SQ   SEQUENCE   277 AA;  30085 MW;  DC4CC2963EC9D007 CRC64;
     MEAMPCHNQR LGAAGGPRPQ DEQTAPAGGC SRLIRFAEPS EGSSSGSPSP DSSSGSNGAA
     AAPSPAAEDC ASPLGAQLKL LPMNDQIREL QTIIRDKTAS RGDFVFSADR LIRLVVEERL
     NQLPYTECTV TTPTGYKYEG VKFEKGNCGV SIMRSGEAME QGLRDCCRSI RIGKILIQSD
     EETQRAKVYY AKFPPDIYRR KVLLMYPILS TGNTVIEAVK VLIEHGVQPS VIILLSLFST
     PHGAKSIIQE FPEITILTTE VHPVAPTHFG QKYFGTD