CABL2_MOUSE
ID CABL2_MOUSE Reviewed; 476 AA.
AC Q8K3M5; A2ABW9;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=CDK5 and ABL1 enzyme substrate 2;
DE AltName: Full=Interactor with CDK3 2;
DE Short=Ik3-2;
GN Name=Cables2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ABL1; CDK3 AND CDK5, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Liver, and Spleen;
RX PubMed=11955625; DOI=10.1016/s0167-4781(01)00367-0;
RA Sato H., Nishimoto I., Matsuoka M.;
RT "Ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-
RT abl.";
RL Biochim. Biophys. Acta 1574:157-163(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Unknown. Probably involved in G1-S cell cycle transition.
CC -!- SUBUNIT: Binds to CDK3, CDK5 and ABL1. The C-terminal cyclin-box-like
CC region binds to CDK5. {ECO:0000269|PubMed:11955625}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11955625}.
CC -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL12171.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY049712; AAL12171.1; ALT_INIT; mRNA.
DR EMBL; AL663027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS38377.1; -.
DR RefSeq; NP_665850.2; NM_145851.2.
DR AlphaFoldDB; Q8K3M5; -.
DR SMR; Q8K3M5; -.
DR BioGRID; 232982; 3.
DR IntAct; Q8K3M5; 1.
DR MINT; Q8K3M5; -.
DR STRING; 10090.ENSMUSP00000104519; -.
DR iPTMnet; Q8K3M5; -.
DR PhosphoSitePlus; Q8K3M5; -.
DR EPD; Q8K3M5; -.
DR MaxQB; Q8K3M5; -.
DR PaxDb; Q8K3M5; -.
DR PRIDE; Q8K3M5; -.
DR ProteomicsDB; 273571; -.
DR Antibodypedia; 29526; 118 antibodies from 22 providers.
DR DNASU; 252966; -.
DR Ensembl; ENSMUST00000108891; ENSMUSP00000104519; ENSMUSG00000038990.
DR GeneID; 252966; -.
DR KEGG; mmu:252966; -.
DR UCSC; uc008oit.1; mouse.
DR CTD; 81928; -.
DR MGI; MGI:2182335; Cables2.
DR VEuPathDB; HostDB:ENSMUSG00000038990; -.
DR eggNOG; KOG4164; Eukaryota.
DR GeneTree; ENSGT00400000022086; -.
DR HOGENOM; CLU_021942_2_1_1; -.
DR InParanoid; Q8K3M5; -.
DR OMA; IAFEFTV; -.
DR OrthoDB; 1441217at2759; -.
DR PhylomeDB; Q8K3M5; -.
DR TreeFam; TF323936; -.
DR BioGRID-ORCS; 252966; 3 hits in 75 CRISPR screens.
DR ChiTaRS; Cables2; mouse.
DR PRO; PR:Q8K3M5; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8K3M5; protein.
DR Bgee; ENSMUSG00000038990; Expressed in granulocyte and 68 other tissues.
DR Genevisible; Q8K3M5; MM.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR012388; CABLES1/2.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR22896; PTHR22896; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF025798; Cables; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Phosphoprotein; Reference proteome.
FT CHAIN 1..476
FT /note="CDK5 and ABL1 enzyme substrate 2"
FT /id="PRO_0000080513"
FT REGION 1..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..26
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..93
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 128
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BTV7"
FT MOD_RES 206
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BTV7"
SQ SEQUENCE 476 AA; 52082 MW; 9557AEFE00B668EC CRC64;
MAAAAAGGAP GPAPGPSRPA PAARNPPAVP RRRGDSRRRQ AALFFLNNIS LDGRPPSLGP
GGEKPAPPPP PPTEAREAPA PPPAPPGGLP GLPARPAPQG LLSPTTAPAG LGLDGQRQRR
RVTSQRCSLE FLEDTVGCAS VQRTKHASGS PRHKGLKKTH FIKNMRQYDT KNSRIVLICA
KRSLCAAFSV LPYGEGLRIS DLRVDSQKQR HPSGGVSVSS EMVFELEGVE LGADGKVVSY
AKFLYPTNAL VIHKNDSHGL LPQPRPSIPR APPGSRHKPV PTKSTPAGTE LGSDGGDAVE
YNPNLLDDPQ WPCGKHKRVL IFASYMTTVI EYVKPADLKK DMNETFREKF PHIKLTLSKI
RSLKREMRNL SEECSLEPVT VSMAYVYFEK LVLQGKLNKQ NRKLCAGACV LLAAKISSDL
RKSEVKQLID KLEERFRFNR KDLIGFEFTV LVALELALYL PENQVLPHYR RLTQQF
