ID   UPP_DANRE               Reviewed;         257 AA.
AC   Q6NYU7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Uracil phosphoribosyltransferase homolog;
GN   Name=uprt; ORFNames=zgc:77421;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPRTase family. {ECO:0000305}.
CC   -!- CAUTION: The uracil binding region known from UPRTases is missing.
CC       {ECO:0000305}.
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DR   EMBL; BC066455; AAH66455.1; -; mRNA.
DR   RefSeq; NP_996974.1; NM_207091.1.
DR   AlphaFoldDB; Q6NYU7; -.
DR   SMR; Q6NYU7; -.
DR   STRING; 7955.ENSDARP00000051528; -.
DR   PaxDb; Q6NYU7; -.
DR   PRIDE; Q6NYU7; -.
DR   GeneID; 404623; -.
DR   KEGG; dre:404623; -.
DR   CTD; 139596; -.
DR   ZFIN; ZDB-GENE-040426-2411; uprt.
DR   eggNOG; KOG1017; Eukaryota.
DR   InParanoid; Q6NYU7; -.
DR   OrthoDB; 929897at2759; -.
DR   PhylomeDB; Q6NYU7; -.
DR   PRO; PR:Q6NYU7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   SUPFAM; SSF53271; SSF53271; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..257
FT                   /note="Uracil phosphoribosyltransferase homolog"
FT                   /id="PRO_0000254538"
FT   BINDING         81
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         90
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         124..127
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         134
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         151
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         180
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         186..194
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         247..249
FT                   /ligand="uracil"
FT                   /ligand_id="ChEBI:CHEBI:17568"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
SQ   SEQUENCE   257 AA;  28806 MW;  5AC949E4E2EE01E9 CRC64;
     MPCHNQQLNN NSESPEHAAK HVRFAQSSAA AAETCQNDAE QPEYQTTSEI HQQIGPQLKL
     LPLNDQIREL QTIIRDKTTS RGDFVFCADR LIRLVVEEGL NQLPYSECTV TTPTGHKYEG
     VKFEKGNCGV SIMRSGEAME QGLRDCCRSI RIGKILIQSD EETQKAKVYY AKFPPDISRR
     KVLLMYPILS TGNTVIEAVR VLTEHGLQAK HIILLSLFST PHGARSIVQE FPDITILTTE
     VHAVAPTHFG QRYFGTD