ID   UPP_MACFA               Reviewed;         309 AA.
AC   Q95KB0; Q95K91; Q95KJ5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Uracil phosphoribosyltransferase homolog;
GN   Name=UPRT; ORFNames=QmoA-12555, QtrA-10339;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RX   PubMed=11806829; DOI=10.1186/gb-2001-3-1-research0006;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Prediction of unidentified human genes on the basis of sequence similarity
RT   to novel cDNAs from cynomolgus monkey brain.";
RL   Genome Biol. 3:RESEARCH0006.1-RESEARCH0006.5(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Medulla oblongata;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPRTase family. {ECO:0000305}.
CC   -!- CAUTION: The uracil binding region known from UPRTases is missing.
CC       {ECO:0000305}.
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DR   EMBL; AB063019; BAB60766.1; -; mRNA.
DR   EMBL; AB063065; BAB60785.1; -; mRNA.
DR   EMBL; AB060829; BAB46861.1; -; mRNA.
DR   RefSeq; NP_001273070.1; NM_001286141.1.
DR   AlphaFoldDB; Q95KB0; -.
DR   SMR; Q95KB0; -.
DR   STRING; 9541.XP_005594037.1; -.
DR   PRIDE; Q95KB0; -.
DR   GeneID; 102116138; -.
DR   CTD; 139596; -.
DR   VEuPathDB; HostDB:ENSMFAG00000002447; -.
DR   eggNOG; KOG1017; Eukaryota.
DR   OMA; NLFCTPM; -.
DR   OrthoDB; 929897at2759; -.
DR   Proteomes; UP000233100; Chromosome X.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   SUPFAM; SSF53271; SSF53271; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..309
FT                   /note="Uracil phosphoribosyltransferase homolog"
FT                   /id="PRO_0000254536"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         133
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         142
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         176..179
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         186
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         203
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         232
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         238..246
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   BINDING         299..301
FT                   /ligand="uracil"
FT                   /ligand_id="ChEBI:CHEBI:17568"
FT                   /evidence="ECO:0000250|UniProtKB:Q26998"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:B1AVZ0"
FT   CONFLICT        101
FT                   /note="E -> K (in Ref. 2; BAB60785)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        108
FT                   /note="A -> V (in Ref. 2; BAB60785)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        125
FT                   /note="I -> V (in Ref. 2; BAB46861)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   309 AA;  33762 MW;  27F4AF2986618487 CRC64;
     MATELQCPDS MPCHNQQVNS ASTPSPEQLR PGDPILDHAG GNRASRAKVT LLTGHTHCSL
     PAELDAGACV GSSLNSESNS GSGDSSSYDA PAGNSFLGDC ELSRQIGAQL KLLPMNDQIR
     ELQTIIRDKT ASRGDFMFSA DRLIRLVVEE GLNQLPYKEC MVTTPTGYKY EGVKFEKGNC
     GVSIMRSGEA MEQGLRDCCR SIRIGKILIQ SDEETQRAKV YYAKFPPDIY RRKVLLMYPI
     LSTGNTVIEA VKVLIEHGVQ PSVIILLSLF STPHGAKSII QEFPEITILT TEVHPVAPTH
     FGQKYFGTD