CABP7_MOUSE
ID CABP7_MOUSE Reviewed; 215 AA.
AC Q91ZM8;
DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Calcium-binding protein 7;
DE Short=CaBP7;
DE AltName: Full=Calneuron II;
DE AltName: Full=Calneuron-2;
GN Name=Cabp7; Synonyms=Caln2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RA Haeseleer F., Palczewski K.;
RT "Calcium-binding protein with similarity to calmodulin.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negatively regulates Golgi-to-plasma membrane trafficking by
CC interacting with PI4KB and inhibiting its activity. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PI4KB. This binding competes with FREQ/NCS1
CC binding in a calcium-dependent manner (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
CC Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane
CC {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
CC -!- DOMAIN: The C-terminal transmembrane domain (TMD) is necessary and
CC sufficient for membrane targeting. {ECO:0000250}.
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DR EMBL; AF419324; AAL14997.1; -; mRNA.
DR CCDS; CCDS24390.1; -.
DR RefSeq; NP_620398.1; NM_138948.3.
DR AlphaFoldDB; Q91ZM8; -.
DR BMRB; Q91ZM8; -.
DR SMR; Q91ZM8; -.
DR STRING; 10090.ENSMUSP00000009219; -.
DR iPTMnet; Q91ZM8; -.
DR PhosphoSitePlus; Q91ZM8; -.
DR PaxDb; Q91ZM8; -.
DR PRIDE; Q91ZM8; -.
DR ProteomicsDB; 273819; -.
DR Antibodypedia; 24571; 115 antibodies from 28 providers.
DR DNASU; 192650; -.
DR Ensembl; ENSMUST00000009219; ENSMUSP00000009219; ENSMUSG00000009075.
DR GeneID; 192650; -.
DR KEGG; mmu:192650; -.
DR UCSC; uc007hve.1; mouse.
DR CTD; 164633; -.
DR MGI; MGI:2183437; Cabp7.
DR VEuPathDB; HostDB:ENSMUSG00000009075; -.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00940000159368; -.
DR HOGENOM; CLU_106115_0_0_1; -.
DR InParanoid; Q91ZM8; -.
DR OMA; CPVEVET; -.
DR OrthoDB; 1542616at2759; -.
DR PhylomeDB; Q91ZM8; -.
DR TreeFam; TF331025; -.
DR BioGRID-ORCS; 192650; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q91ZM8; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q91ZM8; protein.
DR Bgee; ENSMUSG00000009075; Expressed in pontine nuclear group and 71 other tissues.
DR ExpressionAtlas; Q91ZM8; baseline and differential.
DR Genevisible; Q91ZM8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032588; C:trans-Golgi network membrane; IDA:MGI.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 2: Evidence at transcript level;
KW Calcium; Cell membrane; Cytoplasm; Golgi apparatus; Membrane;
KW Metal-binding; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..215
FT /note="Calcium-binding protein 7"
FT /id="PRO_0000073527"
FT TOPO_DOM 1..188
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..215
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 33..68
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 69..104
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 46
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 48
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 50
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 57
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 82
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 84
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 86
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 88
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 93
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 215 AA; 24453 MW; 9C254C955F7AFFA8 CRC64;
MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN GFISKQELGT
AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP KLSTSGIPEK FHGTDFDTVF
WKCDMQKLTV DELKRLLYDT FCEHLSMKDI ENIIMTEEES HLGTAEECPV DVETCSNQQI
RQTCVRKSLI CAFAIAFIIS VMLIAANQVL RSGMK
