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CABP7_RAT
ID   CABP7_RAT               Reviewed;         215 AA.
AC   Q66H96;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Calcium-binding protein 7;
DE            Short=CaBP7;
DE   AltName: Full=Calneuron II;
DE   AltName: Full=Calneuron-2;
GN   Name=Cabp7; Synonyms=Caln2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RA   Kim H., Hong S.;
RT   "Rat calcium binding protein 7.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=17055077; DOI=10.1016/j.bbamcr.2006.08.047;
RA   Mikhaylova M., Sharma Y., Reissner C., Nagel F., Aravind P., Rajini B.,
RA   Smalla K.-H., Gundelfinger E.D., Kreutz M.R.;
RT   "Neuronal Ca2+ signaling via caldendrin and calneurons.";
RL   Biochim. Biophys. Acta 1763:1229-1237(2006).
RN   [4]
RP   SUBCELLULAR LOCATION, INTERACTION WITH PI4KB, AND FUNCTION.
RX   PubMed=19458041; DOI=10.1073/pnas.0903001106;
RA   Mikhaylova M., Reddy P.P., Munsch T., Landgraf P., Suman S.K.,
RA   Smalla K.-H., Gundelfinger E.D., Sharma Y., Kreutz M.R.;
RT   "Calneurons provide a calcium threshold for trans-Golgi network to plasma
RT   membrane trafficking.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:9093-9098(2009).
CC   -!- FUNCTION: Negatively regulates Golgi-to-plasma membrane trafficking by
CC       interacting with PI4KB and inhibiting its activity.
CC       {ECO:0000269|PubMed:19458041}.
CC   -!- SUBUNIT: Interacts with PI4KB. This binding competes with FREQ/NCS1
CC       binding in a calcium-dependent manner. {ECO:0000269|PubMed:19458041}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000305|PubMed:19458041}; Single-pass type IV membrane protein
CC       {ECO:0000305|PubMed:19458041}. Cytoplasm, perinuclear region
CC       {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type IV
CC       membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Brain-specific. Restricted to the CA3 region of the
CC       hippocampus, entorhinal cortex, the antero-dorsal and antero-ventral
CC       thalamus and the inferior and superior colliculus.
CC       {ECO:0000269|PubMed:17055077}.
CC   -!- DOMAIN: The C-terminal transmembrane domain (TMD) is necessary and
CC       sufficient for membrane targeting. {ECO:0000250}.
CC   -!- MISCELLANEOUS: The calcium-binding affinity is not regulated by
CC       magnesium.
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DR   EMBL; AY841152; AAW21810.1; -; mRNA.
DR   EMBL; BC081959; AAH81959.1; -; mRNA.
DR   RefSeq; NP_001007731.1; NM_001007730.2.
DR   AlphaFoldDB; Q66H96; -.
DR   BMRB; Q66H96; -.
DR   SMR; Q66H96; -.
DR   STRING; 10116.ENSRNOP00000010439; -.
DR   PaxDb; Q66H96; -.
DR   Ensembl; ENSRNOT00000078179; ENSRNOP00000074795; ENSRNOG00000057703.
DR   GeneID; 360970; -.
DR   KEGG; rno:360970; -.
DR   UCSC; RGD:1359269; rat.
DR   CTD; 164633; -.
DR   RGD; 1359269; Cabp7.
DR   eggNOG; KOG0027; Eukaryota.
DR   GeneTree; ENSGT00940000159368; -.
DR   HOGENOM; CLU_106115_0_0_1; -.
DR   InParanoid; Q66H96; -.
DR   OMA; CPVEVET; -.
DR   OrthoDB; 1542616at2759; -.
DR   PhylomeDB; Q66H96; -.
DR   TreeFam; TF331025; -.
DR   PRO; PR:Q66H96; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000057703; Expressed in cerebellum and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032588; C:trans-Golgi network membrane; ISO:RGD.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   1: Evidence at protein level;
KW   Calcium; Cell membrane; Cytoplasm; Golgi apparatus; Membrane;
KW   Metal-binding; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..215
FT                   /note="Calcium-binding protein 7"
FT                   /id="PRO_0000383472"
FT   TOPO_DOM        1..188
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..215
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          33..68
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          69..104
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         46
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         48
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         50
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         57
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         82
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         84
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         86
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         88
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         93
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ   SEQUENCE   215 AA;  24453 MW;  9C254C955F7AFFA8 CRC64;
     MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN GFISKQELGT
     AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP KLSTSGIPEK FHGTDFDTVF
     WKCDMQKLTV DELKRLLYDT FCEHLSMKDI ENIIMTEEES HLGTAEECPV DVETCSNQQI
     RQTCVRKSLI CAFAIAFIIS VMLIAANQVL RSGMK
 
 
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