ID   CABS1_BOVIN             Reviewed;         388 AA.
AC   Q2TBJ9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Calcium-binding and spermatid-specific protein 1;
GN   Name=CABS1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Calcium-binding protein (By similarity). Essential for
CC       maintaining the structural integrity of the sperm flagella (By
CC       similarity). {ECO:0000250|UniProtKB:Q68FX6,
CC       ECO:0000250|UniProtKB:Q8C633}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q68FX6}.
CC       Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q68FX6}. Cell
CC       projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8C633}.
CC       Cytoplasmic vesicle, secretory vesicle, acrosome
CC       {ECO:0000250|UniProtKB:Q8C633}. Note=Mostly cytoplasmic, but associated
CC       with the mitochondrial inner membrane during the last steps of
CC       spermatid differentiation. Localizes to the principal piece of the
CC       sperm flagellum (By similarity). {ECO:0000250|UniProtKB:Q68FX6,
CC       ECO:0000250|UniProtKB:Q8C633}.
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DR   EMBL; BC110036; AAI10037.1; -; mRNA.
DR   RefSeq; NP_001035629.1; NM_001040539.1.
DR   AlphaFoldDB; Q2TBJ9; -.
DR   STRING; 9913.ENSBTAP00000026444; -.
DR   PaxDb; Q2TBJ9; -.
DR   Ensembl; ENSBTAT00000026444; ENSBTAP00000026444; ENSBTAG00000019849.
DR   GeneID; 519098; -.
DR   KEGG; bta:519098; -.
DR   CTD; 85438; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019849; -.
DR   VGNC; VGNC:26668; CABS1.
DR   eggNOG; ENOG502RWWC; Eukaryota.
DR   GeneTree; ENSGT00390000015647; -.
DR   HOGENOM; CLU_719537_0_0_1; -.
DR   InParanoid; Q2TBJ9; -.
DR   OMA; KITEPFS; -.
DR   OrthoDB; 1176309at2759; -.
DR   TreeFam; TF338174; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000019849; Expressed in semen and 13 other tissues.
DR   GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR   GO; GO:0097228; C:sperm principal piece; ISS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IBA:GO_Central.
DR   InterPro; IPR026118; Ca-bd_spermatid.
DR   PANTHER; PTHR22810; PTHR22810; 2.
DR   Pfam; PF15367; CABS1; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cell projection; Cilium; Cytoplasm; Cytoplasmic vesicle;
KW   Flagellum; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..388
FT                   /note="Calcium-binding and spermatid-specific protein 1"
FT                   /id="PRO_0000339177"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         280
FT                   /note="Phosphothreonine; by CK2"
FT                   /evidence="ECO:0000250|UniProtKB:Q68FX6"
FT   MOD_RES         312
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q68FX6"
FT   MOD_RES         344
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q68FX6"
SQ   SEQUENCE   388 AA;  42773 MW;  E56055772C02CBE9 CRC64;
     MAEDGLPKIY SHPPAESTKT TTEATIFFGA DNTIPKSETT ITSEGDHVTS VNDYMLENDF
     STTTGNKLIP PKERQKSEDD VESHLEKEFA TLMDIKNPMA NESITENFLP VKTGNISSTD
     AISLIDFSTD IAKEDILLDT IDPGDKDVSL TSEVSGTPKE STAAIADTPI LPNIMGKSDV
     SNYSSSVKFK VPADGNAHIT DSSVPEAEIT PTTERNLTTI PDITALTEEK ITEIDLILPE
     NDPNVVPKLT DSDEEKFITV FELTTTAERD KDNPEDALLT DEESTDEVSV WMERDMANEE
     ESHSVLLTAV ESRYDFVIPA SVTMNLTEDL LTEEDLPENN RMESVTKNTD ELSGTTPDLD
     AFSHKEDNFT TETGVFKLLK EEPDEFLI