CAC1A_CHICK
ID CAC1A_CHICK Reviewed; 171 AA.
AC O73705;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha-1A;
DE AltName: Full=CHCACHA1A;
DE AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.1;
DE Flags: Fragment;
GN Name=CACNA1A;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn; TISSUE=Brain;
RX PubMed=9405708; DOI=10.1073/pnas.94.26.14883;
RA Kollmar R., Montgomery L.G., Fak J., Henry L.J., Hudspeth A.J.;
RT "Predominance of the alpha1D subunit in L-type voltage-gated Ca2+ channels
RT of hair cells in the chicken's cochlea.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:14883-14888(1997).
CC -!- FUNCTION: The isoform alpha-1A gives rise to P and/or Q-type calcium
CC currents. P/Q-type calcium channels belong to the 'high-voltage
CC activated' (HVA) group. {ECO:0000250|UniProtKB:O00555}.
CC -!- SUBUNIT: Voltage-dependent calcium channels are multisubunit complexes,
CC consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1
CC ratio. The channel activity is directed by the pore-forming and
CC voltage-sensitive alpha-1 subunit. In many cases, this subunit is
CC sufficient to generate voltage-sensitive calcium channel activity. The
CC auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge
CC regulate the channel activity. {ECO:0000250|UniProtKB:O00555}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O00555};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- DOMAIN: Each of the four internal repeats contains five hydrophobic
CC transmembrane segments (S1, S2, S3, S5, S6) and one positively charged
CC transmembrane segment (S4). S4 segments probably represent the voltage-
CC sensor and are characterized by a series of positively charged amino
CC acids at every third position.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. CACNA1A subfamily. {ECO:0000305}.
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DR EMBL; AF027608; AAC08309.1; -; mRNA.
DR AlphaFoldDB; O73705; -.
DR SMR; O73705; -.
DR VEuPathDB; HostDB:geneid_374169; -.
DR InParanoid; O73705; -.
DR PhylomeDB; O73705; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IBA:GO_Central.
DR GO; GO:0008331; F:high voltage-gated calcium channel activity; ISS:UniProtKB.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; ISS:UniProtKB.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.350; -; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00167; CACHANNEL.
PE 2: Evidence at transcript level;
KW Calcium; Calcium channel; Calcium transport; Cell membrane; Disulfide bond;
KW Ion channel; Ion transport; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN <1..>171
FT /note="Voltage-dependent P/Q-type calcium channel subunit
FT alpha-1A"
FT /id="PRO_0000053920"
FT TRANSMEM <1..11
FT /note="Helical; Name=S3 of repeat IV"
FT /evidence="ECO:0000255"
FT TOPO_DOM 12..18
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..37
FT /note="Helical; Name=S4 of repeat IV"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..76
FT /note="Helical; Name=S5 of repeat IV"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..143
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..168
FT /note="Helical; Name=S6 of repeat IV"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..>171
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT <1..>171
FT /note="IV"
FT SITE 117
FT /note="Calcium ion selectivity and permeability"
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 171
SQ SEQUENCE 171 AA; 19657 MW; E15B68BD845AE888 CRC64;
FVTVLGSITD ILVTEFGNNF INLSFLRLFR AARLIKLLRQ GYTIRILLWT FVQSFKALPY
VCLLIAMLFF IYAIIGMQVF GNIGIEEEDD ESAITQHNNF RTFFQALMLL FRSATGEAWH
EIMLSCLSGK PCDENSGIKE DECGNEFAYF YFVSFIFLCS FLMLNLFVAV I
