ID   UPS1_SCHPO              Reviewed;         171 AA.
AC   Q9UT07;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Protein ups1 homolog;
GN   ORFNames=SPAP8A3.10;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Required for maintenance of normal mitochondrial morphology
CC       as well as PCP1-dependent processing of MGM1.
CC       {ECO:0000250|UniProtKB:Q05776}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Intermembrane side
CC       {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329670; CAB55177.1; -; Genomic_DNA.
DR   PIR; T39247; T39247.
DR   RefSeq; NP_594949.1; NM_001020380.2.
DR   AlphaFoldDB; Q9UT07; -.
DR   SMR; Q9UT07; -.
DR   STRING; 4896.SPAP8A3.10.1; -.
DR   MaxQB; Q9UT07; -.
DR   PaxDb; Q9UT07; -.
DR   EnsemblFungi; SPAP8A3.10.1; SPAP8A3.10.1:pep; SPAP8A3.10.
DR   GeneID; 2542962; -.
DR   KEGG; spo:SPAP8A3.10; -.
DR   PomBase; SPAP8A3.10; -.
DR   VEuPathDB; FungiDB:SPAP8A3.10; -.
DR   eggNOG; KOG3337; Eukaryota.
DR   HOGENOM; CLU_067902_3_1_1; -.
DR   InParanoid; Q9UT07; -.
DR   OMA; LAFFNRY; -.
DR   PhylomeDB; Q9UT07; -.
DR   Reactome; R-SPO-6803204; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.
DR   PRO; PR:Q9UT07; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:1990050; F:phosphatidic acid transfer activity; ISO:PomBase.
DR   GO; GO:0007006; P:mitochondrial membrane organization; IC:PomBase.
DR   GO; GO:0045332; P:phospholipid translocation; ISO:PomBase.
DR   GO; GO:0015914; P:phospholipid transport; IBA:GO_Central.
DR   InterPro; IPR006797; PRELI/MSF1_dom.
DR   InterPro; IPR037365; Slowmo/Ups.
DR   PANTHER; PTHR11158; PTHR11158; 1.
DR   Pfam; PF04707; PRELI; 1.
DR   PROSITE; PS50904; PRELI_MSF1; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome.
FT   CHAIN           1..171
FT                   /note="Protein ups1 homolog"
FT                   /id="PRO_0000271268"
FT   DOMAIN          2..171
FT                   /note="PRELI/MSF1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
FT   REGION          1..79
FT                   /note="Required for mitochondrial targeting"
FT                   /evidence="ECO:0000250|UniProtKB:Q05776"
SQ   SEQUENCE   171 AA;  19909 MW;  36E9062A4B2BAFDA CRC64;
     MTAICTDKTE LNASWNTVSS AWLTRYPNPY SLHVVSADVL ERYVDDEGRL YTERLLVKQG
     RLPRWASDLL NVNKSYILER SVIDPSKQEL KSETFNLDHV KILRVIEYSR FIQSSENCSK
     TIVDTIAKFV SPLRFGLGRR VQKYSLKRFQ EQLSSSRRGL LYVIQQKFQP S