UPS3_ARATH
ID UPS3_ARATH Reviewed; 344 AA.
AC Q9ZPR6; Q1PFA0;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2015, sequence version 3.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Ureide permease 3 {ECO:0000303|PubMed:11971139};
DE Short=AtUPS3 {ECO:0000303|PubMed:11971139};
GN Name=UPS3 {ECO:0000303|PubMed:11971139};
GN OrderedLocusNames=At2g03600 {ECO:0000312|Araport:AT2G03600};
GN ORFNames=F19B11.5 {ECO:0000312|EMBL:AAD20068.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-344 (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11971139; DOI=10.1105/tpc.010458;
RA Desimone M., Catoni E., Ludewig U., Hilpert M., Schneider A., Kunze R.,
RA Tegeder M., Frommer W.B., Schumacher K.;
RT "A novel superfamily of transporters for allantoin and other oxo
RT derivatives of nitrogen heterocyclic compounds in Arabidopsis.";
RL Plant Cell 14:847-856(2002).
CC -!- FUNCTION: Proton-coupled transporter that transports a wide spectrum of
CC oxo derivatives of heterocyclic nitrogen compounds.
CC {ECO:0000250|UniProtKB:Q9ZPR7}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9ZPR6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ZPR6-2; Sequence=VSP_057674, VSP_057675;
CC -!- SIMILARITY: Belongs to the plant ureide permease (TC 2.A.7.19) family.
CC {ECO:0000305}.
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DR EMBL; AC006836; AAD20068.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05719.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62084.1; -; Genomic_DNA.
DR EMBL; DQ446463; ABE65799.1; -; mRNA.
DR PIR; D84450; D84450.
DR RefSeq; NP_001118258.1; NM_001124786.2.
DR RefSeq; NP_001324264.1; NM_001335193.1. [Q9ZPR6-2]
DR RefSeq; NP_178458.2; NM_126410.2. [Q9ZPR6-2]
DR AlphaFoldDB; Q9ZPR6; -.
DR EnsemblPlants; AT2G03600.1; AT2G03600.1; AT2G03600. [Q9ZPR6-2]
DR EnsemblPlants; AT2G03600.6; AT2G03600.6; AT2G03600. [Q9ZPR6-2]
DR GeneID; 814889; -.
DR Gramene; AT2G03600.1; AT2G03600.1; AT2G03600. [Q9ZPR6-2]
DR Gramene; AT2G03600.6; AT2G03600.6; AT2G03600. [Q9ZPR6-2]
DR KEGG; ath:AT2G03600; -.
DR Araport; AT2G03600; -.
DR InParanoid; Q9ZPR6; -.
DR PRO; PR:Q9ZPR6; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZPR6; baseline and differential.
DR Genevisible; Q9ZPR6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005274; F:allantoin:proton symporter activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0015505; F:uracil:cation symporter activity; IBA:GO_Central.
DR InterPro; IPR030189; UPS_plant.
DR InterPro; IPR009834; Ureide_permease.
DR PANTHER; PTHR31081; PTHR31081; 2.
DR Pfam; PF07168; Ureide_permease; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..344
FT /note="Ureide permease 3"
FT /id="PRO_0000221647"
FT TOPO_DOM 1..10
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..78
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..136
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..235
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..344
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT BINDING 209..216
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 228..256
FT /note="VPKLNVYTAFFYFSISSFGVGLILNIIFL -> GICFSLISPAVSLATNDQW
FT HTLKHGVGTL (in isoform 2)"
FT /id="VSP_057674"
FT VAR_SEQ 257..344
FT /note="Missing (in isoform 2)"
FT /id="VSP_057675"
SQ SEQUENCE 344 AA; 37634 MW; 2850CC2E6611C575 CRC64;
MYVIESKGGT ITCMLLALLF LGTWPAIMTL TERRGRLPQH TYLDYTLTNL LAAVIIAFTL
GEISPSRPNF TTQLSQDNWP SVMFAMAGGI FLSLGTLATQ YAWAFVGLSV TEVITASIAV
VIGTTLNYFL DDRINRAEVL FPGVACFLIA VCFGSAVHKS NAADNKSKLQ GFKSLETTSS
FQMETSSIKE GKAKVGTADF LIEVEKQRAI KVFGKSTIIG LAITFFAVPK LNVYTAFFYF
SISSFGVGLI LNIIFLYWPI LGLPRSSFKA YLNDWNGRGW SFLAGFLCGF GNGLQFMGGQ
AAGYAAAGAV QIENKHFGGY CCLENTKDHQ EKHIHFLSVC YLCS
