ID   UPSA_UNIPI              Reviewed;         125 AA.
AC   K0P7H2;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2012, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Upsalin;
DE   Flags: Precursor;
OS   Unio pictorum (Painter's mussel).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Heteroconchia; Palaeoheterodonta; Unionida; Unionoidea;
OC   Unionidae; Unioninae; Unio.
OX   NCBI_TaxID=55837;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 31-61; 66-90 AND 109-123,
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND GLYCOSYLATION.
RC   TISSUE=Mantle, and Shell;
RX   PubMed=22474002; DOI=10.1002/cbic.201100708;
RA   Ramos-Silva P., Benhamada S., Le Roy N., Marie B., Guichard N.,
RA   Zanella-Cleon I., Plasseraud L., Corneillat M., Alcaraz G., Kaandorp J.,
RA   Marin F.;
RT   "Novel molluskan biomineralization proteins retrieved from proteomics: a
RT   case study with Upsalin.";
RL   ChemBioChem 13:1067-1078(2012).
RN   [2]
RP   PROTEIN SEQUENCE OF 91-100 AND 107-123.
RX   PubMed=20815006; DOI=10.1002/cbic.201000276;
RA   Marie B., Zanella-Cleon I., Le Roy N., Becchi M., Luquet G., Marin F.;
RT   "Proteomic analysis of the acid-soluble nacre matrix of the bivalve Unio
RT   pictorum: detection of novel carbonic anhydrase and putative protease
RT   inhibitor proteins.";
RL   ChemBioChem 11:2138-2147(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22474002}.
CC   -!- TISSUE SPECIFICITY: Expressed at highest levels in mantle, followed by
CC       adductor muscle. Found in the nacreous shell layer (at protein level).
CC       {ECO:0000269|PubMed:22474002}.
CC   -!- PTM: Weakly glycosylated. {ECO:0000269|PubMed:22474002}.
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DR   EMBL; HE994141; CCM44291.1; -; mRNA.
DR   AlphaFoldDB; K0P7H2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..125
FT                   /note="Upsalin"
FT                   /id="PRO_0000429542"
SQ   SEQUENCE   125 AA;  14007 MW;  C55468C0CE20C0C1 CRC64;
     MFPTHVLLIV IACVTAFVYG GGGKRPRVCR YSSDGPVCRT NIECSDPEVH CYRKPGHPYG
     RCCVKRPYAC PRGSSNRYDD PEGFPPLVQR CPYAYPFFCR PGYYCRTKTG GSTEFYGVCC
     PLRVG