ID   UPTI_PIG                Reviewed;         122 AA.
AC   Q29100;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Uterine plasmin/trypsin inhibitor;
DE            Short=UPTI;
DE   Flags: Precursor;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-56, AND
RP   CHARACTERIZATION.
RC   TISSUE=Conceptus membrane, and Uterus;
RX   PubMed=7929061; DOI=10.1016/s0021-9258(19)51051-1;
RA   Stallings-Mann M.L., Burke M.G., Trout W.E., Roberts R.M.;
RT   "Purification, characterization, and cDNA cloning of a Kunitz-type
RT   proteinase inhibitor secreted by the porcine uterus.";
RL   J. Biol. Chem. 269:24090-24094(1994).
CC   -!- FUNCTION: Inhibitor of plasmin and trypsin. Also has a weak affinity
CC       for chymotrypsin. Could serve to neutralize the activities of one or
CC       more serine proteinases generated by the proliferating trophoblast
CC       during the formation of the noninvasive placenta.
CC   -!- TISSUE SPECIFICITY: Expressed only in the uterus and the endometrium.
CC   -!- DEVELOPMENTAL STAGE: Maximally expressed during pregnancy until day 30
CC       after which levels decrease significantly.
CC   -!- INDUCTION: By progesterone.
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DR   EMBL; L14282; AAA62425.1; -; mRNA.
DR   PIR; A55115; A55115.
DR   RefSeq; NP_999036.1; NM_213871.1.
DR   AlphaFoldDB; Q29100; -.
DR   SMR; Q29100; -.
DR   STRING; 9823.ENSSSCP00000026254; -.
DR   PRIDE; Q29100; -.
DR   GeneID; 396887; -.
DR   CTD; 396887; -.
DR   OrthoDB; 1613899at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   CDD; cd00109; KU; 1.
DR   Gene3D; 4.10.410.10; -; 1.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 1.
DR   SUPFAM; SSF57362; SSF57362; 1.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW   Reference proteome; Serine protease inhibitor; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..29
FT                   /evidence="ECO:0000269|PubMed:7929061"
FT                   /id="PRO_0000016881"
FT   CHAIN           30..122
FT                   /note="Uterine plasmin/trypsin inhibitor"
FT                   /id="PRO_0000016882"
FT   DOMAIN          38..88
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   SITE            48..49
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..88
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        47..71
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        63..84
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   CONFLICT        36
FT                   /note="G -> A (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        48
FT                   /note="S -> R (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        52
FT                   /note="V -> I (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        54
FT                   /note="Y -> V (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   122 AA;  13109 MW;  B9BEFB3A6FB76CEC CRC64;
     MSRLCLSAAL LLLLGALVAS TPGDEESSLV RAGPPGFCRE PPYTGPCSAH FVRYFYNATT
     GLCQSFVYGG CRGKQNNFMD EKECLHTCDT CAKAQGKRGN CASEMLKSTR PQGWAVAAFQ
     MG