UQCC2_BOVIN
ID UQCC2_BOVIN Reviewed; 136 AA.
AC Q3SZ13; Q58DH5;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Ubiquinol-cytochrome-c reductase complex assembly factor 2;
DE AltName: Full=Mitochondrial nucleoid factor 1;
DE AltName: Full=Mitochondrial protein M19;
DE Flags: Precursor;
GN Name=UQCC2; Synonyms=MNF1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the assembly of the ubiquinol-cytochrome c
CC reductase complex (mitochondrial respiratory chain complex III or
CC cytochrome b-c1 complex). Plays a role in the modulation of respiratory
CC chain activities such as oxygen consumption and ATP production and via
CC its modulation of the respiratory chain activity can regulate skeletal
CC muscle differentiation and insulin secretion by pancreatic beta-cells.
CC Involved in cytochrome b translation and/or stability.
CC {ECO:0000250|UniProtKB:Q9BRT2, ECO:0000250|UniProtKB:Q9CQY6}.
CC -!- SUBUNIT: Interacts with UQCC1. {ECO:0000250|UniProtKB:Q9BRT2}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC {ECO:0000250}. Mitochondrion {ECO:0000250}. Mitochondrion intermembrane
CC space {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Mitochondrion
CC inner membrane {ECO:0000250}. Note=Predominantly expressed in the
CC mitochondrial inner membrane. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3SZ13-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3SZ13-2; Sequence=VSP_042620;
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DR EMBL; BT021622; AAX46469.1; -; mRNA.
DR EMBL; DAAA02054906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC103264; AAI03265.1; -; mRNA.
DR RefSeq; NP_001193543.1; NM_001206614.1. [Q3SZ13-1]
DR AlphaFoldDB; Q3SZ13; -.
DR Ensembl; ENSBTAT00000047742; ENSBTAP00000044920; ENSBTAG00000054726. [Q3SZ13-1]
DR GeneID; 100607974; -.
DR KEGG; bta:100607974; -.
DR CTD; 84300; -.
DR VEuPathDB; HostDB:ENSBTAG00000054726; -.
DR GeneTree; ENSGT00510000048041; -.
DR HOGENOM; CLU_070591_0_0_1; -.
DR InParanoid; Q3SZ13; -.
DR OMA; YKEKFPR; -.
DR OrthoDB; 1508191at2759; -.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000054726; Expressed in oocyte and 105 other tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR GO; GO:0002082; P:regulation of oxidative phosphorylation; ISS:UniProtKB.
DR GO; GO:2001014; P:regulation of skeletal muscle cell differentiation; ISS:UniProtKB.
DR InterPro; IPR037698; UQCC2.
DR PANTHER; PTHR34260; PTHR34260; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Mitochondrion nucleoid; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..13
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 14..136
FT /note="Ubiquinol-cytochrome-c reductase complex assembly
FT factor 2"
FT /id="PRO_0000416461"
FT REGION 114..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..45
FT /note="MAASRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENT -> MVV
FT QDNVDAPGVPLEPFLHQVGGHLSVMRYDEHTVCKPLISREQRFYESLPLAMKRFTPQYK
FT GTITVHLQKDSRGRLSLVANPLTENRGPFTVSTESAAVAIWQTLQQTTGGSALPLAQWQ
FT HPQRAHSLKESPATALLRSELHLKAQVPSLVEDANGNLTEKGSFNPWGLHCHQAHLSRL
FT CAEYPENKRHRFLLLENVVSQYKHPCILDLKMGTRQHGDDASEEKKARHMRKCAQSTSA
FT HLGMRICGM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16305752"
FT /id="VSP_042620"
FT CONFLICT Q3SZ13-2:6
FT /note="N -> S (in Ref. 2; AAX46469)"
FT /evidence="ECO:0000305"
FT CONFLICT Q3SZ13-2:118
FT /note="A -> T (in Ref. 2; AAX46469)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 136 AA; 15975 MW; 3514C6052AE8B24A CRC64;
MAASRYRRFL KLCEEWPVDE TKRGRDLGAY LRQRVAQAFR EGENTQVAEP EACDEMYESL
ARLHSNYYKH KYPRPRETSF SGLSLEEYKL ILSTDTLDEF KEMNKGTWKK LQEKFAPGSP
EGKHTAWARA LPRPRT
