ID   UQCC2_DANRE             Reviewed;         129 AA.
AC   Q6PBU7;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Ubiquinol-cytochrome-c reductase complex assembly factor 2;
DE   AltName: Full=Mitochondrial nucleoid factor 1;
DE   AltName: Full=Mitochondrial protein M19;
DE   Flags: Precursor;
GN   Name=uqcc2; Synonyms=mnf1; ORFNames=zgc:73238;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Retina;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly of the ubiquinol-cytochrome c
CC       reductase complex (mitochondrial respiratory chain complex III or
CC       cytochrome b-c1 complex). May play a role in the modulation of
CC       respiratory chain activities such as oxygen consumption and ATP
CC       production. May be involved in cytochrome b translation and/or
CC       stability. {ECO:0000250|UniProtKB:Q9BRT2,
CC       ECO:0000250|UniProtKB:Q9CQY6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC       {ECO:0000250}. Mitochondrion {ECO:0000250}.
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DR   EMBL; CU463231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC059579; AAH59579.1; -; mRNA.
DR   RefSeq; NP_957052.1; NM_200758.2.
DR   AlphaFoldDB; Q6PBU7; -.
DR   STRING; 7955.ENSDARP00000005533; -.
DR   PaxDb; Q6PBU7; -.
DR   Ensembl; ENSDART00000004075; ENSDARP00000005533; ENSDARG00000011272.
DR   GeneID; 393731; -.
DR   KEGG; dre:393731; -.
DR   CTD; 84300; -.
DR   ZFIN; ZDB-GENE-040426-1726; uqcc2.
DR   eggNOG; ENOG502S2M4; Eukaryota.
DR   GeneTree; ENSGT00510000048041; -.
DR   HOGENOM; CLU_162766_0_0_1; -.
DR   InParanoid; Q6PBU7; -.
DR   OMA; YKEKFPR; -.
DR   OrthoDB; 1508191at2759; -.
DR   PhylomeDB; Q6PBU7; -.
DR   TreeFam; TF333267; -.
DR   PRO; PR:Q6PBU7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000011272; Expressed in muscle tissue and 33 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:0002082; P:regulation of oxidative phosphorylation; ISS:UniProtKB.
DR   GO; GO:2001014; P:regulation of skeletal muscle cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR037698; UQCC2.
DR   PANTHER; PTHR34260; PTHR34260; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Mitochondrion nucleoid; Reference proteome; Transit peptide.
FT   TRANSIT         1..13
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           14..129
FT                   /note="Ubiquinol-cytochrome-c reductase complex assembly
FT                   factor 2"
FT                   /id="PRO_0000416463"
SQ   SEQUENCE   129 AA;  15021 MW;  F63FBDDDEACF5D70 CRC64;
     MSATRYRRFL KLCEEWPKDE SKKGRDLGTF LRQRVASAFR EGENTQISDP EKCDQMYESL
     ARINSNVYKE KFPRAKDTSF TGVTVEECRL LLATGSMQQT DEEKKGLWKT LMERFSSKPE
     DVPPEKAEK