UQCC2_MOUSE
ID UQCC2_MOUSE Reviewed; 136 AA.
AC Q9CQY6;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Ubiquinol-cytochrome-c reductase complex assembly factor 2;
DE AltName: Full=Mitochondrial nucleoid factor 1;
DE AltName: Full=Mitochondrial protein M19;
DE Flags: Precursor;
GN Name=Uqcc2; Synonyms=Mnf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=19643811; DOI=10.1093/jb/mvp118;
RA Sumitani M., Kasashima K., Ohta E., Kang D., Endo H.;
RT "Association of a novel mitochondrial protein M19 with mitochondrial
RT nucleoids.";
RL J. Biochem. 146:725-732(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND TRANSIT PEPTIDE CLEAVAGE SITE.
RX PubMed=22363741; DOI=10.1371/journal.pone.0031815;
RA Cambier L., Rassam P., Chabi B., Mezghenna K., Gross R., Eveno E.,
RA Auffray C., Wrutniak-Cabello C., Lajoix A.D., Pomies P.;
RT "M19 modulates skeletal muscle differentiation and insulin secretion in
RT pancreatic beta-cells through modulation of respiratory chain activity.";
RL PLoS ONE 7:E31815-E31815(2012).
CC -!- FUNCTION: Required for the assembly of the ubiquinol-cytochrome c
CC reductase complex (mitochondrial respiratory chain complex III or
CC cytochrome b-c1 complex). Plays a role in the modulation of respiratory
CC chain activities such as oxygen consumption and ATP production and via
CC its modulation of the respiratory chain activity can regulate skeletal
CC muscle differentiation and insulin secretion by pancreatic beta-cells.
CC Involved in cytochrome b translation and/or stability.
CC {ECO:0000250|UniProtKB:Q9BRT2, ECO:0000269|PubMed:22363741}.
CC -!- SUBUNIT: Interacts with UQCC1. {ECO:0000250|UniProtKB:Q9BRT2}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC {ECO:0000250}. Mitochondrion {ECO:0000269|PubMed:22363741}.
CC Mitochondrion intermembrane space {ECO:0000269|PubMed:22363741}.
CC Mitochondrion matrix {ECO:0000269|PubMed:22363741}. Mitochondrion inner
CC membrane {ECO:0000269|PubMed:22363741}. Note=Predominantly expressed in
CC the mitochondrial inner membrane.
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in brain,
CC liver, kidney, heart, skeletal muscle, thymus, testis and pancreas (at
CC protein level). {ECO:0000269|PubMed:19643811}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK013521; BAB28896.1; -; mRNA.
DR EMBL; AK019014; BAB31511.1; -; mRNA.
DR EMBL; BC030629; AAH30629.1; -; mRNA.
DR CCDS; CCDS28561.1; -.
DR RefSeq; NP_080339.1; NM_026063.2.
DR AlphaFoldDB; Q9CQY6; -.
DR BioGRID; 212059; 10.
DR STRING; 10090.ENSMUSP00000025045; -.
DR PhosphoSitePlus; Q9CQY6; -.
DR SwissPalm; Q9CQY6; -.
DR EPD; Q9CQY6; -.
DR MaxQB; Q9CQY6; -.
DR PaxDb; Q9CQY6; -.
DR PeptideAtlas; Q9CQY6; -.
DR PRIDE; Q9CQY6; -.
DR ProteomicsDB; 297944; -.
DR Antibodypedia; 64241; 58 antibodies from 17 providers.
DR DNASU; 67267; -.
DR Ensembl; ENSMUST00000025045; ENSMUSP00000025045; ENSMUSG00000024208.
DR GeneID; 67267; -.
DR KEGG; mmu:67267; -.
DR UCSC; uc008bfk.1; mouse.
DR CTD; 84300; -.
DR MGI; MGI:1914517; Uqcc2.
DR VEuPathDB; HostDB:ENSMUSG00000024208; -.
DR eggNOG; ENOG502S2M4; Eukaryota.
DR GeneTree; ENSGT00510000048041; -.
DR InParanoid; Q9CQY6; -.
DR OMA; YKEKFPR; -.
DR OrthoDB; 1508191at2759; -.
DR PhylomeDB; Q9CQY6; -.
DR TreeFam; TF333267; -.
DR BioGRID-ORCS; 67267; 22 hits in 75 CRISPR screens.
DR ChiTaRS; Uqcc2; mouse.
DR PRO; PR:Q9CQY6; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9CQY6; protein.
DR Bgee; ENSMUSG00000024208; Expressed in spermatid and 261 other tissues.
DR ExpressionAtlas; Q9CQY6; baseline and differential.
DR Genevisible; Q9CQY6; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
DR GO; GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
DR GO; GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR GO; GO:0050796; P:regulation of insulin secretion; IMP:UniProtKB.
DR GO; GO:0002082; P:regulation of oxidative phosphorylation; IMP:UniProtKB.
DR GO; GO:2001014; P:regulation of skeletal muscle cell differentiation; IMP:UniProtKB.
DR InterPro; IPR037698; UQCC2.
DR PANTHER; PTHR34260; PTHR34260; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Mitochondrion nucleoid; Reference proteome; Transit peptide.
FT TRANSIT 1..13
FT /note="Mitochondrion"
FT /evidence="ECO:0000269|PubMed:22363741"
FT CHAIN 14..136
FT /note="Ubiquinol-cytochrome-c reductase complex assembly
FT factor 2"
FT /id="PRO_0000089527"
SQ SEQUENCE 136 AA; 16321 MW; 41C5351452ACA16D CRC64;
MAALRYRRFL KLCEEWPVDE TKRGRDLGAY LRQRVAQAFR EGENTQIAEP EACDQMYESL
ARLHSNYYKH KYPRPRDTSF SGLSVEEYKL ILSTDTLEEF QEMNKSMWKK LQEKFAPTRP
EEKHKAWTRV LSRPRT
