ID   UQCC2_RAT               Reviewed;         136 AA.
AC   B5DFN3;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Ubiquinol-cytochrome-c reductase complex assembly factor 2;
DE   AltName: Full=Mitochondrial nucleoid factor 1;
DE   AltName: Full=Mitochondrial protein M19;
DE   Flags: Precursor;
GN   Name=Uqcc2; Synonyms=Mnf1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary anterior lobe;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for the assembly of the ubiquinol-cytochrome c
CC       reductase complex (mitochondrial respiratory chain complex III or
CC       cytochrome b-c1 complex). Plays a role in the modulation of respiratory
CC       chain activities such as oxygen consumption and ATP production and via
CC       its modulation of the respiratory chain activity can regulate skeletal
CC       muscle differentiation and insulin secretion by pancreatic beta-cells.
CC       Involved in cytochrome b translation and/or stability.
CC       {ECO:0000250|UniProtKB:Q9BRT2, ECO:0000250|UniProtKB:Q9CQY6}.
CC   -!- SUBUNIT: Interacts with UQCC1. {ECO:0000250|UniProtKB:Q9BRT2}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC       {ECO:0000250}. Mitochondrion {ECO:0000250}. Mitochondrion intermembrane
CC       space {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Mitochondrion
CC       inner membrane {ECO:0000250}. Note=Predominantly expressed in the
CC       mitochondrial inner membrane. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH473988; EDL96879.1; -; Genomic_DNA.
DR   EMBL; BC169127; AAI69127.1; -; mRNA.
DR   RefSeq; NP_001101998.1; NM_001108528.1.
DR   AlphaFoldDB; B5DFN3; -.
DR   STRING; 10116.ENSRNOP00000036200; -.
DR   iPTMnet; B5DFN3; -.
DR   PhosphoSitePlus; B5DFN3; -.
DR   SwissPalm; B5DFN3; -.
DR   jPOST; B5DFN3; -.
DR   PaxDb; B5DFN3; -.
DR   PeptideAtlas; B5DFN3; -.
DR   PRIDE; B5DFN3; -.
DR   GeneID; 361805; -.
DR   KEGG; rno:361805; -.
DR   UCSC; RGD:1306917; rat.
DR   CTD; 84300; -.
DR   RGD; 1306917; Uqcc2.
DR   VEuPathDB; HostDB:ENSRNOG00000025909; -.
DR   eggNOG; ENOG502S2M4; Eukaryota.
DR   HOGENOM; CLU_162766_0_0_1; -.
DR   InParanoid; B5DFN3; -.
DR   OMA; YKEKFPR; -.
DR   OrthoDB; 1508191at2759; -.
DR   PhylomeDB; B5DFN3; -.
DR   TreeFam; TF333267; -.
DR   PRO; PR:B5DFN3; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Proteomes; UP000234681; Chromosome 20.
DR   Bgee; ENSRNOG00000025909; Expressed in quadriceps femoris and 20 other tissues.
DR   ExpressionAtlas; B5DFN3; baseline and differential.
DR   Genevisible; B5DFN3; RN.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:0002082; P:regulation of oxidative phosphorylation; ISS:UniProtKB.
DR   GO; GO:2001014; P:regulation of skeletal muscle cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR037698; UQCC2.
DR   PANTHER; PTHR34260; PTHR34260; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Mitochondrion nucleoid; Reference proteome; Transit peptide.
FT   TRANSIT         1..13
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           14..136
FT                   /note="Ubiquinol-cytochrome-c reductase complex assembly
FT                   factor 2"
FT                   /id="PRO_0000416462"
SQ   SEQUENCE   136 AA;  16330 MW;  41DBDA0D0FD00E29 CRC64;
     MAALRYRRFL KLCEEWPVDE TKRGRDLGAY LRQRVAQAFR EGENTQVAEP EACDQMYESL
     ARLHSNYYKH KYPRPRDTSF SGLSVEEYKL ILSTDTLEEF QEMNKSVWRK LQEKFAPTRP
     EEKHRAWTRV LSRPRT