CAC1B_CHICK
ID CAC1B_CHICK Reviewed; 159 AA.
AC O73706;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Voltage-dependent N-type calcium channel subunit alpha-1B;
DE AltName: Full=CHCACHA1B;
DE AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.2;
DE Flags: Fragment;
GN Name=CACNA1B;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn; TISSUE=Brain;
RX PubMed=9405708; DOI=10.1073/pnas.94.26.14883;
RA Kollmar R., Montgomery L.G., Fak J., Henry L.J., Hudspeth A.J.;
RT "Predominance of the alpha1D subunit in L-type voltage-gated Ca2+ channels
RT of hair cells in the chicken's cochlea.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:14883-14888(1997).
CC -!- FUNCTION: The isoform alpha-1B gives rise to N-type calcium currents.
CC N-type calcium channels belong to the 'high-voltage activated' (HVA)
CC group. Calcium channels containing alpha-1B subunit may play a role in
CC directed migration of immature neurons (By similarity). Mediates Ca(2+)
CC release probability at hippocampal neuronal soma and synaptic terminals
CC (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q02294}.
CC -!- SUBUNIT: Multisubunit complex consisting of alpha-1, alpha-2, beta and
CC delta subunits in a 1:1:1:1 ratio. The channel activity is directed by
CC the pore-forming and voltage-sensitive alpha-1 subunit. In many cases,
CC this subunit is sufficient to generate voltage-sensitive calcium
CC channel activity. The auxiliary subunits beta and alpha-2/delta linked
CC by a disulfide bridge regulate the channel activity. Interacts with
CC RIMBP2.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- DOMAIN: Each of the four internal repeats contains five hydrophobic
CC transmembrane segments (S1, S2, S3, S5, S6) and one positively charged
CC transmembrane segment (S4). S4 segments probably represent the voltage-
CC sensor and are characterized by a series of positively charged amino
CC acids at every third position.
CC -!- PTM: Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. CACNA1B subfamily. {ECO:0000305}.
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DR EMBL; AF027609; AAC08310.1; -; mRNA.
DR AlphaFoldDB; O73706; -.
DR SMR; O73706; -.
DR STRING; 9031.ENSGALP00000039311; -.
DR PaxDb; O73706; -.
DR VEuPathDB; HostDB:geneid_374169; -.
DR eggNOG; KOG2301; Eukaryota.
DR HOGENOM; CLU_000540_1_0_1; -.
DR InParanoid; O73706; -.
DR OrthoDB; 172471at2759; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0044305; C:calyx of Held; IDA:SynGO.
DR GO; GO:0099056; C:integral component of presynaptic membrane; IDA:SynGO.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IBA:GO_Central.
DR GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005447; VDCC_N_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR PANTHER; PTHR45628:SF6; PTHR45628:SF6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00167; CACHANNEL.
PE 2: Evidence at transcript level;
KW Calcium; Calcium channel; Calcium transport; Disulfide bond; Glycoprotein;
KW Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport;
KW Voltage-gated channel.
FT CHAIN <1..>159
FT /note="Voltage-dependent N-type calcium channel subunit
FT alpha-1B"
FT /id="PRO_0000053925"
FT TRANSMEM <1..5
FT /note="Helical; Name=S3 of repeat IV"
FT /evidence="ECO:0000255"
FT TOPO_DOM 6..13
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..32
FT /note="Helical; Name=S4 of repeat IV"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..71
FT /note="Helical; Name=S5 of repeat IV"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..135
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..155
FT /note="Helical; Name=S6 of repeat IV"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..>159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT <1..>159
FT /note="IV"
FT SITE 105
FT /note="Calcium ion selectivity and permeability"
FT /evidence="ECO:0000250"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 159
SQ SEQUENCE 159 AA; 18327 MW; 07EF613E2AAA992D CRC64;
LVTEIADTDN FINLSFLRLF RAARLIKLLR QGYTIRILLW TFVQSFKALP YVCLLIAMLF
FIYAIIGMQV FGNIALNDET SINRHNNFRT FLQALMLLFR SATGEAWHEI MLSCLSNRAC
DPLSGLTKNE CGSDFAYFYF VSFIFLCSFL MLNLFVAVI
