ID   UQCC3_BOVIN             Reviewed;          95 AA.
AC   Q148G8;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Ubiquinol-cytochrome-c reductase complex assembly factor 3 {ECO:0000250|UniProtKB:Q6UW78};
GN   Name=UQCC3 {ECO:0000250|UniProtKB:Q6UW78};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly of the ubiquinol-cytochrome c
CC       reductase complex (mitochondrial respiratory chain complex III or
CC       cytochrome b-c1 complex), mediating cytochrome b recruitment and
CC       probably stabilization within the complex. Thereby, plays an important
CC       role in ATP production by mitochondria. Cardiolipin-binding protein, it
CC       may also control the cardiolipin composition of mitochondria membranes
CC       and their morphology. {ECO:0000250|UniProtKB:Q6UW78}.
CC   -!- SUBUNIT: Associates with the ubiquinol-cytochrome c reductase complex
CC       (mitochondrial respiratory chain complex III or cytochrome b-c1
CC       complex). {ECO:0000250|UniProtKB:Q6UW78}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q6UW78}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q6UW78}.
CC   -!- PTM: Probably cleaved by OMA1 under mitochondrial stress conditions.
CC       {ECO:0000250|UniProtKB:Q6UW78}.
CC   -!- SIMILARITY: Belongs to the UQCC3 family. {ECO:0000305}.
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DR   EMBL; BC118350; AAI18351.1; -; mRNA.
DR   RefSeq; NP_001069182.1; NM_001075714.2.
DR   AlphaFoldDB; Q148G8; -.
DR   SMR; Q148G8; -.
DR   STRING; 9913.ENSBTAP00000013832; -.
DR   PaxDb; Q148G8; -.
DR   GeneID; 515452; -.
DR   KEGG; bta:515452; -.
DR   CTD; 790955; -.
DR   eggNOG; ENOG502S9VI; Eukaryota.
DR   HOGENOM; CLU_184624_0_0_1; -.
DR   InParanoid; Q148G8; -.
DR   TreeFam; TF339744; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:1901612; F:cardiolipin binding; ISS:UniProtKB.
DR   GO; GO:0070300; F:phosphatidic acid binding; ISS:UniProtKB.
DR   GO; GO:0006754; P:ATP biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR   GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; ISS:UniProtKB.
DR   GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR   InterPro; IPR027896; UQCC3.
DR   PANTHER; PTHR36465; PTHR36465; 1.
DR   Pfam; PF15141; UQCC3; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..95
FT                   /note="Ubiquinol-cytochrome-c reductase complex assembly
FT                   factor 3"
FT                   /id="PRO_0000351680"
FT   TOPO_DOM        1..7
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:Q6UW78"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..95
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q6UW78"
FT   REGION          23..80
FT                   /note="Mediates lipid-binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q6UW78"
SQ   SEQUENCE   95 AA;  9925 MW;  92396A693460FE2B CRC64;
     MTTLRKLLLV GALLGAGAGV GTALFALVTP GEERKQAMLK EMPEQYPQRR DEAARTKELL
     LATLQEAAAT QENVAWRKNW MSGGGGGGGG GGRSA