UQCC3_MOUSE
ID UQCC3_MOUSE Reviewed; 89 AA.
AC Q8K2T4;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Ubiquinol-cytochrome-c reductase complex assembly factor 3 {ECO:0000250|UniProtKB:Q6UW78};
GN Name=Uqcc3 {ECO:0000250|UniProtKB:Q6UW78};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for the assembly of the ubiquinol-cytochrome c
CC reductase complex (mitochondrial respiratory chain complex III or
CC cytochrome b-c1 complex), mediating cytochrome b recruitment and
CC probably stabilization within the complex. Thereby, plays an important
CC role in ATP production by mitochondria. Cardiolipin-binding protein, it
CC may also control the cardiolipin composition of mitochondria membranes
CC and their morphology. {ECO:0000250|UniProtKB:Q6UW78}.
CC -!- SUBUNIT: Associates with the ubiquinol-cytochrome c reductase complex
CC (mitochondrial respiratory chain complex III or cytochrome b-c1
CC complex). {ECO:0000250|UniProtKB:Q6UW78}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q6UW78}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q6UW78}.
CC -!- PTM: Probably cleaved by OMA1 under mitochondrial stress conditions.
CC {ECO:0000250|UniProtKB:Q6UW78}.
CC -!- SIMILARITY: Belongs to the UQCC3 family. {ECO:0000305}.
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DR EMBL; BC029863; AAH29863.1; -; mRNA.
DR CCDS; CCDS50383.1; -.
DR RefSeq; NP_001153828.1; NM_001160356.1.
DR AlphaFoldDB; Q8K2T4; -.
DR SMR; Q8K2T4; -.
DR STRING; 10090.ENSMUSP00000093972; -.
DR iPTMnet; Q8K2T4; -.
DR PhosphoSitePlus; Q8K2T4; -.
DR MaxQB; Q8K2T4; -.
DR PaxDb; Q8K2T4; -.
DR PRIDE; Q8K2T4; -.
DR ProteomicsDB; 300191; -.
DR Antibodypedia; 63885; 10 antibodies from 9 providers.
DR Ensembl; ENSMUST00000096253; ENSMUSP00000093972; ENSMUSG00000071654.
DR GeneID; 107197; -.
DR KEGG; mmu:107197; -.
DR UCSC; uc008gnr.2; mouse.
DR CTD; 790955; -.
DR MGI; MGI:2147553; Uqcc3.
DR VEuPathDB; HostDB:ENSMUSG00000071654; -.
DR eggNOG; ENOG502S9VI; Eukaryota.
DR GeneTree; ENSGT00390000001930; -.
DR HOGENOM; CLU_184624_0_0_1; -.
DR InParanoid; Q8K2T4; -.
DR OMA; VAWRKDW; -.
DR OrthoDB; 1568049at2759; -.
DR PhylomeDB; Q8K2T4; -.
DR TreeFam; TF339744; -.
DR BioGRID-ORCS; 107197; 7 hits in 71 CRISPR screens.
DR ChiTaRS; Uqcc3; mouse.
DR PRO; PR:Q8K2T4; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8K2T4; protein.
DR Bgee; ENSMUSG00000071654; Expressed in retinal neural layer and 256 other tissues.
DR ExpressionAtlas; Q8K2T4; baseline and differential.
DR Genevisible; Q8K2T4; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005750; C:mitochondrial respiratory chain complex III; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:1901612; F:cardiolipin binding; ISS:UniProtKB.
DR GO; GO:0070300; F:phosphatidic acid binding; ISS:UniProtKB.
DR GO; GO:0006754; P:ATP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; ISS:UniProtKB.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR InterPro; IPR027896; UQCC3.
DR PANTHER; PTHR36465; PTHR36465; 1.
DR Pfam; PF15141; UQCC3; 1.
PE 1: Evidence at protein level;
KW ATP synthesis; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..89
FT /note="Ubiquinol-cytochrome-c reductase complex assembly
FT factor 3"
FT /id="PRO_0000022612"
FT TOPO_DOM 1..7
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:Q6UW78"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..89
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q6UW78"
FT REGION 23..80
FT /note="Mediates lipid-binding"
FT /evidence="ECO:0000250|UniProtKB:Q6UW78"
SQ SEQUENCE 89 AA; 9584 MW; 49A995ABACD9040E CRC64;
MEVARKALVA VAVLGGGAGV GSILFALVTP GELQKQSMLQ EMPERDSRRR DEAVRTTELV
MATLKDAAAT KENVAWRRNW TVSGDGRSA
