ID   UQCC3_XENLA             Reviewed;          82 AA.
AC   Q2KP58;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Ubiquinol-cytochrome-c reductase complex assembly factor 3 {ECO:0000250|UniProtKB:Q6UW78};
DE   AltName: Full=Oocyte antigen VAP18;
GN   Name=uqcc3 {ECO:0000250|UniProtKB:Q6UW78};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yang H.S., Lai S., Ruan X.Z., Zhao X.Y., Song M., Liao J., Wei Y.Q.;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly of the ubiquinol-cytochrome c
CC       reductase complex (mitochondrial respiratory chain complex III or
CC       cytochrome b-c1 complex), mediating cytochrome b recruitment and
CC       probably stabilization within the complex. Thereby, plays an important
CC       role in ATP production by mitochondria. Cardiolipin-binding protein, it
CC       may also control the cardiolipin composition of mitochondria membranes
CC       and their morphology. {ECO:0000250|UniProtKB:Q6UW78}.
CC   -!- SUBUNIT: Associates with the ubiquinol-cytochrome c reductase complex
CC       (mitochondrial respiratory chain complex III or cytochrome b-c1
CC       complex). {ECO:0000250|UniProtKB:Q6UW78}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q6UW78}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q6UW78}.
CC   -!- SIMILARITY: Belongs to the UQCC3 family. {ECO:0000305}.
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DR   EMBL; AY850274; AAW65537.1; -; mRNA.
DR   RefSeq; NP_001089152.1; NM_001095683.1.
DR   AlphaFoldDB; Q2KP58; -.
DR   GeneID; 734185; -.
DR   KEGG; xla:734185; -.
DR   CTD; 734185; -.
DR   Xenbase; XB-GENE-6251847; uqcc3.L.
DR   OrthoDB; 1568049at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 734185; Expressed in brain and 20 other tissues.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:1901612; F:cardiolipin binding; ISS:UniProtKB.
DR   GO; GO:0070300; F:phosphatidic acid binding; ISS:UniProtKB.
DR   GO; GO:0006754; P:ATP biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR   GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; ISS:UniProtKB.
DR   GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR   InterPro; IPR027896; UQCC3.
DR   PANTHER; PTHR36465; PTHR36465; 1.
DR   Pfam; PF15141; UQCC3; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..82
FT                   /note="Ubiquinol-cytochrome-c reductase complex assembly
FT                   factor 3"
FT                   /id="PRO_0000360986"
FT   TOPO_DOM        1..6
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:Q6UW78"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..82
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q6UW78"
SQ   SEQUENCE   82 AA;  9313 MW;  A1DF62C974383A45 CRC64;
     METVRRIVKG TLLLGFCTGI GGDLWVLVAP GQERRLEMRM NYPEANPPML AEAHKRNEMV
     LKVIEESAKT NENMARRSPW SS