UR2R_BOVIN
ID UR2R_BOVIN Reviewed; 384 AA.
AC P49220; Q58DI3;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 2.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Urotensin-2 receptor;
DE Short=UR-2-R;
DE AltName: Full=G-protein coupled receptor 14;
DE AltName: Full=G-protein coupled sensory epithelial neuropeptide-like receptor;
DE Short=SENR;
DE AltName: Full=Urotensin II receptor;
DE Short=UR-II-R;
GN Name=UTS2R; Synonyms=GPR14;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 98-312.
RC TISSUE=Retina;
RX PubMed=7733947; DOI=10.1006/bbrc.1995.1563;
RA Tal M., Ammar D.A., Karpuj M., Krizhanovsky V., Naim M., Thompson D.A.;
RT "A novel putative neuropeptide receptor expressed in neural tissue,
RT including sensory epithelia.";
RL Biochem. Biophys. Res. Commun. 209:752-759(1995).
CC -!- FUNCTION: High affinity receptor for urotensin-2 and urotensin-2B. The
CC activity of this receptor is mediated by a G-protein that activate a
CC phosphatidylinositol-calcium second messenger system (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in neural tissue, including sensory
CC epithelia.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BT021614; AAX46461.1; -; mRNA.
DR EMBL; U23459; AAC48464.1; -; mRNA.
DR RefSeq; NP_001035574.1; NM_001040484.1.
DR AlphaFoldDB; P49220; -.
DR SMR; P49220; -.
DR STRING; 9913.ENSBTAP00000024179; -.
DR PaxDb; P49220; -.
DR GeneID; 286969; -.
DR KEGG; bta:286969; -.
DR CTD; 2837; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P49220; -.
DR OrthoDB; 1076228at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0001604; F:urotensin II receptor activity; IBA:GO_Central.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000670; Urot_II_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00647; UROTENSIN2R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..384
FT /note="Urotensin-2 receptor"
FT /id="PRO_0000070192"
FT TOPO_DOM 1..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..113
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..124
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..146
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..285
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..299
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..384
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 123..199
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 244
FT /note="S -> A (in Ref. 2; AAC48464)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 384 AA; 42316 MW; CE747C0DBEFFB4A5 CRC64;
MALSPEPSSR FLVPATMGSA MPELPGAPNA SLNSSLASPT EPNSLEDLVA TGTIGVVLSA
MGVVGMAGNV YTLTVMCRFL HTSASMYVYV INLALADLLY LLSIPFIVAT YVTKRWHFGD
VGCRVLFSLD FLTMHASIFT LTLMSRERYA AVVRPLDTVQ RSKGYRKVLA LGTWLLALLL
ALPMMLAIRL VRRGHKSLCL PAWGQRTHRA YLTLLFGTSI VGPGVVIGLL YVRLARAYWL
SQRSSFTQTR RLPNPRVLYL ILGIVLLFWA CFLPFWLWQL LAQYRGAPPL APRSARIVNY
LTTCLTYGNS CVNPFLYTLL TKNYRDYRQR SLHSRGTSGP VGVRSFPQGH TRCQLGSGRS
VTSSSQQATE TIALSQAVPG SLCV
