UR2R_MACMU
ID UR2R_MACMU Reviewed; 389 AA.
AC Q8HYC3;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Urotensin-2 receptor;
DE Short=UR-2-R;
DE AltName: Full=Urotensin II receptor;
DE Short=UR-II-R;
GN Name=UTS2R;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11976263; DOI=10.1038/sj.bjp.0704671;
RA Elshourbagy N.A., Douglas S.A., Shabon U., Harrison S., Duddy G.,
RA Sechler J.L., Ao Z., Maleeff B.E., Naselsky D., Disa J., Aiyar N.V.;
RT "Molecular and pharmacological characterization of genes encoding
RT urotensin-II peptides and their cognate G-protein-coupled receptors from
RT the mouse and monkey.";
RL Br. J. Pharmacol. 136:9-22(2002).
CC -!- FUNCTION: High affinity receptor for urotensin-2 and urotensin-2B. The
CC activity of this receptor is mediated by a G-protein that activate a
CC phosphatidylinositol-calcium second messenger system (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY065982; AAL55428.1; -; mRNA.
DR RefSeq; NP_001028066.1; NM_001032894.1.
DR AlphaFoldDB; Q8HYC3; -.
DR SMR; Q8HYC3; -.
DR STRING; 9544.ENSMMUP00000001486; -.
DR ChEMBL; CHEMBL4845; -.
DR GeneID; 574245; -.
DR KEGG; mcc:574245; -.
DR CTD; 2837; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q8HYC3; -.
DR OrthoDB; 1076228at2759; -.
DR PRO; PR:Q8HYC3; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001604; F:urotensin II receptor activity; IEA:InterPro.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000670; Urot_II_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00647; UROTENSIN2R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..389
FT /note="Urotensin-2 receptor"
FT /id="PRO_0000070194"
FT TOPO_DOM 1..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..113
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..124
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..146
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..284
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..297
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..389
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 123..199
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 389 AA; 42126 MW; E74FD612B6886363 CRC64;
MALTPESPSS FPGLAAIGSS VPEPPGSPNA TLNSSWASPT EPSSLEDLVA TGAIGTLLSA
MGVVGVVGNA YTLVVTCRSL RAVASMYIYV VNLALADLLY LLSIPFIVAT YITKEWHFGD
VGCRVLFSLD FLTMHASIFT LTVMSSERYA AVLRPLDTVQ RPKGYRKLLA LGTWLLALLL
TLPVMLAMRL VRRGPKSLCL PAWGPRAHRA YLTLLFATSI AGPGLLIGLL YARLARAYRR
SQRASFKRAR RPGARALRLV LGIVLLFWAC FLPFWLWQLL AQYREAPLAP RTARIVNYLT
TCLTYGNSCA NPFLYTLLTR NYRDHLRGRV RSPGSGGVRG PVPSLQPRAR FQRGSGRSLS
SCSPQPTESL VLAAAAPAGP ALESPGDPA
