UR2R_MOUSE
ID UR2R_MOUSE Reviewed; 385 AA.
AC Q8VIH9;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Urotensin-2 receptor;
DE Short=UR-2-R;
DE AltName: Full=G-protein coupled receptor 14;
DE AltName: Full=Urotensin II receptor;
DE Short=UR-II-R;
GN Name=Uts2r; Synonyms=Gpr14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RA Qi J.-S., Santulli R., de Garavilla L., D'Andrea M., Smith C.,
RA Andrade-Gordon P.;
RT "Mouse urotensin II receptor GPR14.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11976263; DOI=10.1038/sj.bjp.0704671;
RA Elshourbagy N.A., Douglas S.A., Shabon U., Harrison S., Duddy G.,
RA Sechler J.L., Ao Z., Maleeff B.E., Naselsky D., Disa J., Aiyar N.V.;
RT "Molecular and pharmacological characterization of genes encoding
RT urotensin-II peptides and their cognate G-protein-coupled receptors from
RT the mouse and monkey.";
RL Br. J. Pharmacol. 136:9-22(2002).
CC -!- FUNCTION: High affinity receptor for urotensin-2 and urotensin-2B. The
CC activity of this receptor is mediated by a G-protein that activate a
CC phosphatidylinositol-calcium second messenger system (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF441863; AAL34551.1; -; mRNA.
DR EMBL; AY065981; AAL55427.1; -; mRNA.
DR CCDS; CCDS25769.1; -.
DR RefSeq; NP_663415.1; NM_145440.1.
DR AlphaFoldDB; Q8VIH9; -.
DR SMR; Q8VIH9; -.
DR STRING; 10090.ENSMUSP00000046920; -.
DR BindingDB; Q8VIH9; -.
DR ChEMBL; CHEMBL2346494; -.
DR GuidetoPHARMACOLOGY; 365; -.
DR GlyGen; Q8VIH9; 2 sites.
DR iPTMnet; Q8VIH9; -.
DR PhosphoSitePlus; Q8VIH9; -.
DR PaxDb; Q8VIH9; -.
DR PRIDE; Q8VIH9; -.
DR DNASU; 217369; -.
DR Ensembl; ENSMUST00000039044; ENSMUSP00000046920; ENSMUSG00000039321.
DR GeneID; 217369; -.
DR KEGG; mmu:217369; -.
DR UCSC; uc007mvj.1; mouse.
DR CTD; 2837; -.
DR MGI; MGI:2183450; Uts2r.
DR VEuPathDB; HostDB:ENSMUSG00000039321; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000156819; -.
DR HOGENOM; CLU_009579_1_0_1; -.
DR InParanoid; Q8VIH9; -.
DR OMA; WGPRAHR; -.
DR OrthoDB; 1076228at2759; -.
DR PhylomeDB; Q8VIH9; -.
DR TreeFam; TF334200; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 217369; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q8VIH9; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8VIH9; protein.
DR Bgee; ENSMUSG00000039321; Expressed in tarsal region and 22 other tissues.
DR ExpressionAtlas; Q8VIH9; baseline and differential.
DR Genevisible; Q8VIH9; MM.
DR GO; GO:0005769; C:early endosome; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0055037; C:recycling endosome; ISO:MGI.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0001604; F:urotensin II receptor activity; ISO:MGI.
DR GO; GO:0045776; P:negative regulation of blood pressure; ISO:MGI.
DR GO; GO:0003105; P:negative regulation of glomerular filtration; ISO:MGI.
DR GO; GO:0035814; P:negative regulation of renal sodium excretion; ISO:MGI.
DR GO; GO:0035811; P:negative regulation of urine volume; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISO:MGI.
DR GO; GO:0030307; P:positive regulation of cell growth; ISO:MGI.
DR GO; GO:0046005; P:positive regulation of circadian sleep/wake cycle, REM sleep; ISO:MGI.
DR GO; GO:0010841; P:positive regulation of circadian sleep/wake cycle, wakefulness; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISO:MGI.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000670; Urot_II_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00647; UROTENSIN2R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..385
FT /note="Urotensin-2 receptor"
FT /id="PRO_0000070195"
FT TOPO_DOM 1..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..76
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..112
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..145
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..185
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..231
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..283
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..298
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..320
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..385
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 122..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 385 AA; 42523 MW; 64F853C07014B5F7 CRC64;
MALSLESTSF PMLAVSRSTA SELPGGFNVS HNSSWTGPTD PSSLQDLVAT GVIGAVLSTM
GVVGVVGNVY TLVVMCRFLR ASASMYVYVV NLALADLLYL LSIPFIVATY VTKDWHFGDV
GCRVLFSLDF LTMHASIFTL TIMSSERYAA VLRPLDTVQR SKGYRKLLAL GTWLLALLLT
LPMMLAIRLV RRGSKSLCLP AWGPRAHRTY LTLLFGTSIV GPGLVIGLLY IRLARAYWLS
QQASFKQTRR LPNPRVLYLI LGIVLLFWAC FLPFWLWQLL AQYHQAMPLT PETARIINYL
TACLTYGNSC INPFLYTLLT KNYREYLRGR QRSLGSSCRG PGSAGSFLSS RVHLQQDSGR
SLSSNSQQAT ETLVLSPVPP NGAFV
