URAD_HALJB
ID URAD_HALJB Reviewed; 176 AA.
AC D8JBB8;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase;
DE Short=OHCU decarboxylase;
DE EC=4.1.1.97;
GN OrderedLocusNames=HacjB3_16066;
OS Halalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC
OS 4019 / B3).
OG Plasmid 1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halalkalicoccus.
OX NCBI_TaxID=795797;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18796 / CECT 7217 / JCM 14584 / KCTC 4019 / B3;
RX PubMed=20601480; DOI=10.1128/jb.00663-10;
RA Roh S.W., Nam Y.D., Nam S.H., Choi S.H., Park H.S., Bae J.W.;
RT "Complete genome sequence of Halalkalicoccus jeotgali B3(T), an extremely
RT halophilic archaeon.";
RL J. Bacteriol. 192:4528-4529(2010).
CC -!- FUNCTION: Catalyzes the stereoselective decarboxylation of 2-oxo-4-
CC hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-
CC carboxylate + H(+) = (S)-allantoin + CO2; Xref=Rhea:RHEA:26301,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:58639; EC=4.1.1.97;
CC -!- PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from
CC urate: step 3/3.
CC -!- SIMILARITY: Belongs to the OHCU decarboxylase family. {ECO:0000305}.
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DR EMBL; CP002063; ADJ16571.1; -; Genomic_DNA.
DR RefSeq; WP_008413871.1; NZ_AXZD01000014.1.
DR AlphaFoldDB; D8JBB8; -.
DR SMR; D8JBB8; -.
DR STRING; 795797.C497_01185; -.
DR EnsemblBacteria; ADJ16571; ADJ16571; HacjB3_16066.
DR GeneID; 9421016; -.
DR KEGG; hje:HacjB3_16066; -.
DR eggNOG; arCOG11423; Archaea.
DR HOGENOM; CLU_092522_1_1_2; -.
DR OMA; KICHLRL; -.
DR OrthoDB; 98147at2157; -.
DR UniPathway; UPA00394; UER00652.
DR Proteomes; UP000000390; Plasmid 1.
DR GO; GO:0051997; F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity; IEA:RHEA.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0000255; P:allantoin metabolic process; IEA:InterPro.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.3330.10; -; 1.
DR InterPro; IPR018020; OHCU_decarboxylase.
DR InterPro; IPR017580; OHCU_decarboxylase-1.
DR InterPro; IPR036778; OHCU_decarboxylase_sf.
DR Pfam; PF09349; OHCU_decarbox; 1.
DR SUPFAM; SSF158694; SSF158694; 1.
DR TIGRFAMs; TIGR03164; UHCUDC; 1.
PE 3: Inferred from homology;
KW Decarboxylase; Lyase; Oxidoreductase; Plasmid; Purine metabolism;
KW Reference proteome.
FT CHAIN 1..176
FT /note="2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
FT decarboxylase"
FT /id="PRO_0000411959"
FT REGION 72..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 70
FT /note="Proton donor; for OHCU decarboxylase activity"
FT /evidence="ECO:0000250"
FT BINDING 71
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 83..87
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 118..122
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 176 AA; 20035 MW; 15D10FC8457C8D4C CRC64;
MTRLTVEDLN QADKERFVDA VGDVYEESPW VAKRTWSEQP FSSIDGLQQA MANTVQDASQ
QKQLELLRAH PDLGERTEMT DESQEEQASA GLDRLPPAQY ETFQTLNDTY RDKFGFPFIM
AVKDESVGTI QQAMEDRIDH SRSKEFQTAL NEVNVIAALR LEELTVPRDG TQEQHA
