URAD_HALVD
ID URAD_HALVD Reviewed; 168 AA.
AC D4GPU8;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase;
DE Short=OHCU decarboxylase;
DE EC=4.1.1.97;
GN OrderedLocusNames=HVO_B0301;
OS Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OG Plasmid pHV3.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=309800;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC B-1768 / DS2;
RX PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT "The complete genome sequence of Haloferax volcanii DS2, a model
RT archaeon.";
RL PLoS ONE 5:E9605-E9605(2010).
CC -!- FUNCTION: Catalyzes the stereoselective decarboxylation of 2-oxo-4-
CC hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-
CC carboxylate + H(+) = (S)-allantoin + CO2; Xref=Rhea:RHEA:26301,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:58639; EC=4.1.1.97;
CC -!- PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from
CC urate: step 3/3.
CC -!- SIMILARITY: Belongs to the OHCU decarboxylase family. {ECO:0000305}.
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DR EMBL; CP001953; ADE01468.1; -; Genomic_DNA.
DR RefSeq; WP_004041239.1; NZ_AOHU01000021.1.
DR AlphaFoldDB; D4GPU8; -.
DR SMR; D4GPU8; -.
DR STRING; 309800.C498_02150; -.
DR EnsemblBacteria; ADE01468; ADE01468; HVO_B0301.
DR GeneID; 8919056; -.
DR KEGG; hvo:HVO_B0301; -.
DR eggNOG; arCOG11423; Archaea.
DR HOGENOM; CLU_092522_1_1_2; -.
DR OMA; KICHLRL; -.
DR OrthoDB; 98147at2157; -.
DR UniPathway; UPA00394; UER00652.
DR Proteomes; UP000008243; Plasmid pHV3.
DR GO; GO:0051997; F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity; IEA:RHEA.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0000255; P:allantoin metabolic process; IEA:InterPro.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.3330.10; -; 1.
DR InterPro; IPR018020; OHCU_decarboxylase.
DR InterPro; IPR017580; OHCU_decarboxylase-1.
DR InterPro; IPR036778; OHCU_decarboxylase_sf.
DR Pfam; PF09349; OHCU_decarbox; 1.
DR SUPFAM; SSF158694; SSF158694; 1.
DR TIGRFAMs; TIGR03164; UHCUDC; 1.
PE 3: Inferred from homology;
KW Decarboxylase; Lyase; Oxidoreductase; Plasmid; Purine metabolism;
KW Reference proteome.
FT CHAIN 1..168
FT /note="2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
FT decarboxylase"
FT /id="PRO_0000411958"
FT REGION 70..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 70
FT /note="Proton donor; for OHCU decarboxylase activity"
FT /evidence="ECO:0000250"
FT BINDING 71
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 83..87
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 118..122
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 168 AA; 19373 MW; 4D5CA9344E2CBFA6 CRC64;
MHELTLQQVN RLDDDSFVDA FGEIYEHSPW VAERARSSRP FSSVDELRSA MKRAVEDASR
EKQLQLLRAH PDLGERTEMT DASEAEQASA ELDSLSRSQY ETFQRLNETY RERFGFPFVM
AVKDENPDAI AAAMERRVDH SESTEFRTAL DEVHTIAELR LAERFSSE
