ID   URB2_HUMAN              Reviewed;        1524 AA.
AC   Q14146; Q5VYC9;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Unhealthy ribosome biogenesis protein 2 homolog;
GN   Name=URB2; Synonyms=KIAA0133;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=8590280; DOI=10.1093/dnares/2.4.167;
RA   Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.;
RT   "Prediction of the coding sequences of unidentified human genes. IV. The
RT   coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of
RT   cDNA clones from human cell line KG-1.";
RL   DNA Res. 2:167-174(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP   ANALYSIS].
RX   PubMed=15635413; DOI=10.1038/nature03207;
RA   Andersen J.S., Lam Y.W., Leung A.K.L., Ong S.-E., Lyon C.E., Lamond A.I.,
RA   Mann M.;
RT   "Nucleolar proteome dynamics.";
RL   Nature 433:77-83(2005).
CC   -!- FUNCTION: Essential for hematopietic stem cell development through the
CC       regulation of p53/TP53 pathway. {ECO:0000250|UniProtKB:B0V0U5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15635413}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA09482.3; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D50923; BAA09482.3; ALT_INIT; mRNA.
DR   EMBL; AL354983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL121990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC114559; AAI14560.1; -; mRNA.
DR   EMBL; BC114963; AAI14964.1; -; mRNA.
DR   CCDS; CCDS31052.1; -.
DR   RefSeq; NP_001300950.1; NM_001314021.1.
DR   RefSeq; NP_055592.2; NM_014777.3.
DR   AlphaFoldDB; Q14146; -.
DR   BioGRID; 115155; 106.
DR   IntAct; Q14146; 30.
DR   STRING; 9606.ENSP00000258243; -.
DR   CarbonylDB; Q14146; -.
DR   iPTMnet; Q14146; -.
DR   PhosphoSitePlus; Q14146; -.
DR   SwissPalm; Q14146; -.
DR   BioMuta; URB2; -.
DR   DMDM; 209572635; -.
DR   EPD; Q14146; -.
DR   jPOST; Q14146; -.
DR   MassIVE; Q14146; -.
DR   MaxQB; Q14146; -.
DR   PaxDb; Q14146; -.
DR   PeptideAtlas; Q14146; -.
DR   PRIDE; Q14146; -.
DR   ProteomicsDB; 59850; -.
DR   Antibodypedia; 1890; 77 antibodies from 17 providers.
DR   DNASU; 9816; -.
DR   Ensembl; ENST00000258243.7; ENSP00000258243.2; ENSG00000135763.10.
DR   GeneID; 9816; -.
DR   KEGG; hsa:9816; -.
DR   MANE-Select; ENST00000258243.7; ENSP00000258243.2; NM_014777.4; NP_055592.2.
DR   UCSC; uc001hts.1; human.
DR   CTD; 9816; -.
DR   DisGeNET; 9816; -.
DR   GeneCards; URB2; -.
DR   HGNC; HGNC:28967; URB2.
DR   HPA; ENSG00000135763; Low tissue specificity.
DR   MIM; 619372; gene.
DR   neXtProt; NX_Q14146; -.
DR   OpenTargets; ENSG00000135763; -.
DR   PharmGKB; PA164727496; -.
DR   VEuPathDB; HostDB:ENSG00000135763; -.
DR   eggNOG; ENOG502QWBH; Eukaryota.
DR   GeneTree; ENSGT00390000009258; -.
DR   HOGENOM; CLU_251606_0_0_1; -.
DR   InParanoid; Q14146; -.
DR   OMA; CYLSVQR; -.
DR   OrthoDB; 727255at2759; -.
DR   PhylomeDB; Q14146; -.
DR   TreeFam; TF328770; -.
DR   PathwayCommons; Q14146; -.
DR   SignaLink; Q14146; -.
DR   BioGRID-ORCS; 9816; 573 hits in 1083 CRISPR screens.
DR   ChiTaRS; URB2; human.
DR   GenomeRNAi; 9816; -.
DR   Pharos; Q14146; Tbio.
DR   PRO; PR:Q14146; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q14146; protein.
DR   Bgee; ENSG00000135763; Expressed in gastrocnemius and 125 other tissues.
DR   ExpressionAtlas; Q14146; baseline and differential.
DR   Genevisible; Q14146; HS.
DR   GO; GO:0016235; C:aggresome; IDA:HPA.
DR   GO; GO:0030496; C:midbody; IDA:HGNC.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:1901796; P:regulation of signal transduction by p53 class mediator; ISS:UniProtKB.
DR   GO; GO:0042254; P:ribosome biogenesis; IBA:GO_Central.
DR   InterPro; IPR018849; Urb2/Npa2_C.
DR   Pfam; PF10441; Urb2; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1524
FT                   /note="Unhealthy ribosome biogenesis protein 2 homolog"
FT                   /id="PRO_0000050720"
FT   VARIANT         778
FT                   /note="V -> G (in dbSNP:rs3811473)"
FT                   /id="VAR_034031"
FT   VARIANT         1400
FT                   /note="V -> M (in dbSNP:rs12142450)"
FT                   /id="VAR_046975"
SQ   SEQUENCE   1524 AA;  170544 MW;  D27CFF42B0892679 CRC64;
     MAAVYSGISL KLKSKTTSWE DKLKLAHFAW ISHQCFLPNK EQVLLDWARQ SLVAFYKKKL
     ELKEDIVERL WIYIDNILHS RKLQNLLKNG KTINLQISLV KIINERVAEF SLSGSQRNIC
     AVLRCCQGIL STPALAVIYT AKQELMVALL SQLCWSACRQ PEGAVVAQLF EVIHLALGHY
     LLILQQQVNP RRAFGDVTAH LLQPCLVLRH LLSGGTWTQA GQGQLRQVLS RDIRSQIEAM
     FRGGIFQPEL LSSYKEGLLD QQQGDVKTGA MKNLLAPMDT VLNRLVDAGY CAASLHTSVV
     ANSVALLYKL FLDSYFKEGN QLLCFQVLPR LFGCLKISHL QEEQSKALST SDWTTELLVV
     EQLLNSVANN NIYNIAADRI RHEEAQFRFY RHVAELLINH AQAPIPAWFR CLKTLISLNH
     LILEPDLDDL LASAWIDAEV TEFRTKKAQE ALIRTVFQTY AKLRQVPRLF EEVLGVICRP
     AAEALRQPVL ASGPSTVLSA CLLELPPSQI LDTWSLVLEK FQSLVLPYLQ SDADMALKSL
     SLSLLLHCIM FNMRSLDSST PLPIVRRTQC MMERMMRELV QPLLALLPDT PGPEPELWLQ
     KVSDSVLLLS YTWAQVDAMF SLNCSQYHSM SGPLIGVALE ISNLPSLLPG VKTQHWKKIE
     KFTAQFSSLG TYCLEQLYLQ KMKRTLMQTS FRSEGAIQSL RCDAAFIIGS GRKSLNQRTT
     ASWDGQVGMV SGLTYPVAHW HLIVSNLTIL ISYLCPDDVG YLASVLLRTL PMGKAQEVSI
     DEEAYITLEK ISKAFLHSPL FPEMQSLHSA FLTCVTTSCS SILCSGAQRD SGLVSQQLPW
     LFEKDHMVVG HWENRFAKAG PEGIEPRGEI AQNLLSLVKS DFPIQLEGEQ LESILGLLEV
     ISALQLDSLL PPYHVHYFLV LLSMAVTKLG CSCSSSLALK FLTTCYQLLG YLQKGKSARS
     VFKIMYGSDI FEVVLTSLFR ASSRFLIEMD DPAWLEFLQV IGTFLEELMQ MLIQMKLSLV
     LNFRKITAFL SSSKPYTEAA SSKQLENQNP QGRQLLLVSL TRLCHVLGPF LKEQKLGQEA
     PAALSELLQQ VVLQTGAVLQ LCSVPGARGW RLPSVLISSV STLLEADLGQ HCRDGGADIS
     QGSDRTLLSH VALYQGVYSQ ILLELPALAG HDQSFQAALQ FLTLFFLAPE LHPKKDSVFT
     SMFHSVRRVL ADPEIPVQVT QDIEPHLGAL FTQMLEVGTT EDLRLVMQCI LQGLDVSNMW
     KADVQAVVSA VTLLRLLLNC PLSGEKASLL WRACPQIVTA LTLLNREASQ EQPVSLTVVG
     PVLDVLAALL RQGEEAIGNP HHVSLAFSIL LTVPLDHLKP LEYGSVFPRL HNVLFSILQC
     HPKVMLKAIP SFLNSFNRLV FSVMREGRQK DKGSIDDLPT VLKCARLVER MYSHIAARAE
     EFAVFSPFMV AQYVLEVQKV TLYPAVKSLL QEGIYLILDL CIEPDVQFLR ASLQPGMRDI
     FKELYNDYLK YHKAKHEGEK RYTA